Early-onset colorectal cancer: more than one side to the story

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2020-09-01 DOI:10.2217/crc-2020-0016

N. Sanford, Pooja Dharwadkar, C. Murphy

引用次数: 5

Abstract

Aim: To determine the impact of tumor sidedness on all-cause mortality for early- (age 18–49 years) and older-onset (age ≥50 years) colorectal cancer (CRC). Materials & methods: We conducted a retrospective study of 650,382 patients diagnosed with CRC between 2000 and 2016. We examined the associations of age, tumor sidedness (right colon, left colon and rectum) and all-cause mortality. Results: For early-onset CRC (n = 66,186), mortality was highest in the youngest age group (18–29 years), driven by left-sided colon cancers (vs 50–59 years, hazard ratio: 1.18; 95% CI: 1.03–1.34). 5-year risk of death among 18–29-year-olds with left-sided colon cancer (0.42, 95% CI: 0.38, 0.46) was higher than all other age groups. Conclusion: Left-sided colon cancers are enriched in younger adults and may be disproportionately fatal.

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早期发病的癌症：故事的多方面

目的：确定肿瘤侧性对早期（18-49岁）和老年（≥50岁）癌症（CRC）全因死亡率的影响。材料与方法：我们对2000年至2016年间诊断为CRC的650382名患者进行了回顾性研究。我们研究了年龄、肿瘤侧性（右半结肠、左半结肠和直肠）和全因死亡率的关系。结果：对于早发性CRC（n=66186），最年轻年龄组（18-29岁）的死亡率最高，主要是左侧结肠癌（与50-59岁相比，风险比：1.18；95%CI:1.03–1.34）。18-29岁左侧结肠癌癌症患者的5年死亡风险（0.42，95%CI:0.38，0.46）高于所有其他年龄组。结论：左侧结肠癌在年轻人中富集，可能致命性过高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.