Development of Successful Physiologically-Based Pharmacokinetic (PBPK) Models

Q3 Pharmacology, Toxicology and Pharmaceutics

Jordan Journal of Pharmaceutical Sciences Pub Date : 2023-07-24 DOI:10.35516/jjps.v16i2.1491

N. Idkaidek

引用次数: 0

Abstract

Physiologically-based pharmacokinetic (PBPK) modeling is a strong mathematical tool that integrates body physiology, drug physicochemical properties and pharmacokinetics to predict detailed drug profiles in different parts of the body. PBPK modeling can also be used to predict the effects of drug-drug interactions and diseases on drug pharmacokinetics. The use of special modules enables the extrapolation to different routes and also different species. PBPK steps for successful modeling will be discussed with examples using GastroPlus program. Such in-silico work can minimize the number and risks of in vivo clinical studies done on healthy subjects or on patients.

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成功建立基于生理的药代动力学(PBPK)模型

基于生理的药代动力学(PBPK)建模是一种强大的数学工具，它集成了身体生理学，药物物理化学性质和药代动力学，以预测身体不同部位的详细药物特征。PBPK模型还可用于预测药物-药物相互作用和疾病对药物药代动力学的影响。特殊模块的使用使外推到不同的路线和不同的物种。PBPK步骤的成功建模将通过使用GastroPlus程序的例子进行讨论。这种计算机化工作可以最大限度地减少对健康受试者或患者进行体内临床研究的数量和风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jordan Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Jordan Journal of Pharmaceutical Sciences (JJPS) is a scientific, bi-annual, peer-reviewed publication that will focus on current topics of interest to the pharmaceutical community at large. Although the JJPS is intended to be of interest to pharmaceutical scientists, other healthy workers, and manufacturing processors will also find it most interesting and informative. Papers will cover basic pharmaceutical and applied research, scientific commentaries, as well as views, reviews. Topics on products will include manufacturing process, quality control, pharmaceutical engineering, pharmaceutical technology, and philosophies on all aspects of pharmaceutical sciences. The editorial advisory board would like to place an emphasis on new and innovative methods, technologies, and techniques for the pharmaceutical industry. The reader will find a broad range of important topics in this first issue.