Efficacy and safety of intravenous combined with topical administration of tranexamic acid in reducing blood loss in opening wedge high tibial osteotomy procedure: A retrospective case-control study

IF 1.1 4区医学 Q3 ORTHOPEDICS

Acta orthopaedica et traumatologica turcica Pub Date : 2022-03-01 DOI:10.5152/j.aott.2022.21138

W. Luo, Xin Fu, Jingmin Huang, Jiang Wu, Xin-long Ma

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引用次数: 1

Abstract

Objective: This study aimed to evaluate the efficacy and safety of intravenous combined with topical application of tranexamic acid (TXA) in reducing blood loss in opening wedge high tibial osteotomy (OWHTO). Methods: A total of 60 patients who underwent unilateral OWHTO between May 2018 and May 2019 were retrospectively reviewed. All the patients were then divided into one of the two groups (30 per group): the TXA group, patients receiving intravenous combined with topical application of TXA, and the control group, patients receiving no TXA. Outcome measures were drain volume, total blood loss, hidden blood loss, transfusion requirements, and incidence of complications. Results: The mean follow-up of TXA group was 14.2 2.3 months (range, 13-16 months) and the mean follow-up for the control group was 14.4 2.1 months (range, 13-17 months). No significant difference was found for the follow-up of two groups (P = 0.829). Drainage volume (143.3 65.4 ml vs 307.8 51.4 mL, P < 0.001), hidden blood loss (156.7 63.8 mL vs 286.4 79.1 mL, P < 0.001) and knee swelling (3.2 0.9 vs 6.5 2.1, P < 0.001) in the TXA group was clearly less than that in the control group, and there was no statistical significance with regard to hospitalization time (P = 0.746), transfusion requirements (P = 1.000), wound complications (P = 0.386), deep venous thrombosis (P = 1.000), postoperative Lysholm knee score (P = 0.681) and Knee Injury & Osteoarthritis Outcome subscales pain (P = 0.752), symptoms (P = 0.673), activities of daily living (P = 0.871), sport/recreation function (P = 0.816), and knee-related quality of life (P = 0.576) at 6 months postoperatively. Conclusion: This study has shown that administration of intravenous combined with topical TXA in OWHTO can effectively reduce perioperative blood loss without increasing the incidence of postoperative complications.

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静脉联合局部给药氨甲环酸减少开楔形高位胫骨截骨术出血量的有效性和安全性:回顾性病例对照研究

目的:评价静脉联合外用氨甲环酸(TXA)减少开口楔形高位胫骨截骨术(OWHTO)出血量的疗效和安全性。方法:回顾性分析2018年5月至2019年5月期间接受单侧OWHTO治疗的60例患者。然后将所有患者分为两组(每组30人):TXA组，接受静脉联合局部应用TXA的患者，和对照组，不接受TXA的患者。结果测量为引流量、总失血量、隐性失血量、输血需求和并发症发生率。结果:TXA组平均随访14.2 ~ 2.3个月(范围13 ~ 16个月)，对照组平均随访14.4 ~ 2.1个月(范围13 ~ 17个月)。两组随访比较差异无统计学意义(P = 0.829)。排水体积(143.3 vs 65.4毫升307.8 51.4毫升,P < 0.001),隐性失血(156.7 vs 63.8毫升286.4 - 79.1 ml, P < 0.001)和膝关节肿胀(3.2 - 0.9 vs 6.5 - 2.1, P < 0.001)酸组明显少于对照组,并没有统计学意义对住院时间(P = 0.746),输血需求(P = 1.000),伤口并发症(P = 0.386),深静脉血栓形成(P = 1.000),术后6个月Lysholm膝关节评分(P = 0.681)和膝关节损伤与骨关节炎结局亚量表疼痛(P = 0.752)、症状(P = 0.673)、日常生活活动(P = 0.871)、运动/娱乐功能(P = 0.816)和膝关节相关生活质量(P = 0.576)。结论:本研究表明，OWHTO患者静脉联合外用TXA可有效减少围手术期出血量，且不增加术后并发症的发生率。

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来源期刊

Acta orthopaedica et traumatologica turcica ORTHOPEDICS-

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Orthopaedica et Traumatologica Turcica (AOTT) is an international, scientific, open access periodical published in accordance with independent, unbiased, and double-blinded peer-review principles. The journal is the official publication of the Turkish Association of Orthopaedics and Traumatology, and Turkish Society of Orthopaedics and Traumatology. It is published bimonthly in January, March, May, July, September, and November. The publication language of the journal is English. The aim of the journal is to publish original studies of the highest scientific and clinical value in orthopedics, traumatology, and related disciplines. The scope of the journal includes but not limited to diagnostic, treatment, and prevention methods related to orthopedics and traumatology. Acta Orthopaedica et Traumatologica Turcica publishes clinical and basic research articles, case reports, personal clinical and technical notes, systematic reviews and meta-analyses and letters to the Editor. Proceedings of scientific meetings are also considered for publication. The target audience of the journal includes healthcare professionals, physicians, and researchers who are interested or working in orthopedics and traumatology field, and related disciplines.