RESULTS OF THE USE OF POLYVALENT BACTERIOPHAGES IN THE TREATMENT OF INFECTIOUS COMPLICATIONS IN EMERGENCY ABDOMINAL SURGERY

Abstract

We comparatively studied the results of treatment of 86 patients with surgical infectious complications after cavitary intra-abdominal operations for emergency abdominal diseases. In the main group, treatment was supplemented with polyvalent bacteriophages. We studied integral scales for assessing the severity of patient’s condition of (APACHE II, ACI, ASEPSIS), microbial pattern, enteral morphofunctional coefficient, levels of alkaline phosphatase and intestinal alkaline phosphatase, and indicators of cellular immunity. The results of the study show that complex treatment including polyvalent bacteriophages in postoperative purulent-inflammatory complications in urgent surgery reduces the development of antibiotic-resistant strains, as well as the risk of nosocomial microbial wound associations. Enteral application of polyvalent bacteriophages in patients with acute intestinal failure syndrome normalizes microbial enteral imbalance and the level of pathogens contamination of the small intestine. Supplementing the treatment of postoperative abdominal purulent-inflammatory complications with phage therapy can reduce the number of surgical interventions, as well as the treatment duration and mortality.