Game Theory Cancer Models of Cancer Cell-Stromal Cell Dynamics using Interacting Particle Systems

Abstract

We describe an evolutionary game theory model that has been used to predict the population dynamics of interacting cancer and stromal cells. We first consider the mean field case assuming homogeneous and nondiscrete populations. Interacting Particle Systems (IPS) are then presented as a discrete and spatial alternative to the mean field approach. Finally, we discuss cases where IPS gives results different from the mean field approach.