The detection rate of pertussis in children and infants with persistent cough in Beijing during 2011-2016

中华传染病杂志 Pub Date : 2018-11-15 DOI:10.3760/CMA.J.ISSN.1000-6680.2018.11.005

Yang Zhao, Jin Fu, F. Xiao, Li Li, Baoyuan Zhang, Yanwei Li, Xuelian Han, X. Cui, Qing-ping Duan

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Abstract

Objective To investigate the prevalence of pertussis in infants and children with persistent cough in Beijing during 2011-2016. Methods The eligible infants and children from over ten hospitals who were suspected to have pertussis from 2011 to 2016 were enrolled for detection. Nasopharyngeal secretions and blood samples were collected. Multiplex-PCR was performed for Bordetella pertussis and real-time PCR was performed for nucleic acid of Bordetella pertussis. Results A total of 1 318 eligible cases were enrolled, including 820 males and 498 females. Pertussis was detected positive in 534 cases, including 81.3% (434/534) of B. pertussis positive cases and 31.8% (170/534) of IgG positive cases. There were 13.1% (70/534) had double positive for bacteria and antibodies. From 2011 to 2016, the enrolled patients were increased from 103 cases per year to 460 cases per year, and the test positive patients were increased from 29 cases to 194 cases. Among the pertussis patients, 466 (87.3%) cases were younger than one year old. From the first quarter to the fourth quarter of the year, There were 65 cases, 151 cases, 205 cases, and 113 cases, respectively. In further analysis of the 268 cases from Children′s Hospital affiliated to Capital Institute of Pediatrics, 90.7% of the patients who had whooping cough were scattered children; 185 cases (69.0%) of the patients had not begun programmed immunization, 71 cases (26.5%) did not complete programmed immunization and 12 cases (4.5%) completed the programmed immunization. Of all the inpatients, 21.6% were critical ill, 0.8% (2 cases) dead, and the remaining patients were recovered and discharged. Conclusions The prevalence of pertussis is increasing, especially in summer. Infants are the most susceptible population. Bordetella pertussis is one of the most important pathogen that can induce persistent and chronic cough. Key words: Whooping cough; Epidemiology; Polymerase chain reaction

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北京市2011-2016年持续咳嗽患儿百日咳检出率

目的了解北京市2011-2016年婴幼儿持续性咳嗽百日咳流行情况。方法对2011-2016年10多家医院符合条件的疑似百日咳患儿进行检测。采集鼻咽分泌物和血液样本。对百日咳杆菌进行多重PCR，对百日咳杆菌核酸进行实时PCR。结果共有1318例符合条件的病例入选，其中男性820例，女性498例。在534例中检测到百日咳阳性，其中81.3%（434/534）的百日咳杆菌阳性病例和31.8%（170/534）IgG阳性病例。细菌和抗体双重阳性者占13.1%（70/534）。从2011年到2016年，入选患者从每年103例增加到每年460例，检测呈阳性的患者从29例增加到194例。在百日咳患者中，466例（87.3%）病例年龄小于一岁。从今年第一季度到第四季度，分别有65例、151例、205例和113例。进一步分析首都儿科研究所附属儿童医院268例百日咳患者中，90.7%为散居儿童；185例（69.0%）未开始程序免疫，71例（26.5%）未完成程序免疫，12例（4.5%）完成程序免疫。在所有住院患者中，21.6%的患者病情危重，0.8%（2例）死亡，其余患者已康复出院。结论百日咳发病率呈上升趋势，尤其是在夏季。婴儿是最易受感染的人群。百日咳杆菌是引起持续性和慢性咳嗽的最重要病原体之一。关键词：百日咳；流行病学；聚合酶链式反应

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来源期刊

中华传染病杂志

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发文量

5280

期刊介绍： The Chinese Journal of Infectious Diseases was founded in February 1983. It is an academic journal on infectious diseases supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by the Shanghai Medical Association. The journal targets infectious disease physicians as its main readers, taking into account physicians of other interdisciplinary disciplines, and timely reports on leading scientific research results and clinical diagnosis and treatment experience in the field of infectious diseases, as well as basic theoretical research that has a guiding role in the clinical practice of infectious diseases and is closely integrated with the actual clinical practice of infectious diseases. Columns include reviews (including editor-in-chief reviews), expert lectures, consensus and guidelines (including interpretations), monographs, short monographs, academic debates, epidemic news, international dynamics, case reports, reviews, lectures, meeting minutes, etc.