Maximizing value and minimizing waste in clinical trials in swine: Selecting outcomes to build an evidence base

IF 0.7 4区农林科学 Q3 Agricultural and Biological Sciences

Journal of Swine Health and Production Pub Date : 2023-01-01 DOI:10.54846/jshap/1300

J. Sargeant, A. O'Connor, T. O’Sullivan, A. Ramirez

引用次数: 1

Abstract

Researchers planning clinical trials should identify the primary trial outcome and adequately power the trial to detect clinically meaningful differences in this outcome. All primary and secondary outcomes and their measurement should be comprehensively described, and their results reported. There is evidence that trials on the same subject use different outcomes or measure the same outcome in different ways, making it difficult to compare intervention effectiveness across clinical trials. Consensus development of core outcome sets could improve consistency in outcome measures used across trials and aid in development of an evidence-based body of literature on intervention effectiveness in swine populations.

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在猪临床试验中实现价值最大化和废物最小化：选择结果以建立证据基础

计划临床试验的研究人员应确定主要试验结果，并充分推动试验以发现该结果的临床意义差异。所有主要和次要结局及其测量应全面描述，并报告其结果。有证据表明，同一主题的试验使用不同的结果或以不同的方式衡量相同的结果，这使得很难比较不同临床试验的干预效果。核心结果集的共识发展可以提高试验中使用的结果测量的一致性，并有助于建立以证据为基础的猪群干预有效性文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Swine Health and Production 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： The Journal of Swine Health & Production (JSHAP) is an open-access and peer-reviewed journal published by the American Association of Swine Veterinarians (AASV) since 1993. The aim of the journal is the timely publication of peer-reviewed papers with a scope that encompasses the many domains of applied swine health and production, including the diagnosis, treatment, management, prevention and eradication of swine diseases, welfare & behavior, nutrition, public health, epidemiology, food safety, biosecurity, pharmaceuticals, antimicrobial use and resistance, reproduction, growth, systems flow, economics, and facility design. The journal provides a platform for researchers, veterinary practitioners, academics, and students to share their work with an international audience. The journal publishes information that contains an applied and practical focus and presents scientific information that is accessible to the busy veterinary practitioner as well as to the research and academic community. Hence, manuscripts with an applied focus are considered for publication, and the journal publishes original research, brief communications, case reports/series, literature reviews, commentaries, diagnostic notes, production tools, and practice tips. All manuscripts submitted to the Journal of Swine Health & Production are peer-reviewed.