Relationship between 25-hydroxyvitamin D and ovarian reserve in premenopausal Nigerian women

C. Makwe, Z. Aliyu
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引用次数: 2

Abstract

Context: Despite the increasing knowledge about the potential effect of vitamin D deficiency on ovarian reserve of premenopausal women, the burden of this disorder among 'at risk' women in sub-Saharan Africa is notably scanty. Aims: To determine the prevalence of vitamin D deficiency among premenopausal Nigerian women To assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum anti-mullerian hormone (AMH). Settings and Design: A prospective cross-sectional study of 218 premenopausal Nigerian women, attending a tertiary hospital in Lagos. Materials and Methods: Serum levels of 25(OH)D and AMH were assayed using ELIZA technique, for each eligible participant. Statistical Analysis Used: To determine the association between serum vitamin D and serum AMH were Kruskal-Wallis test and Pearson's correlation coefficient. Data analysis was performed on 211 participants with complete data. Results: The mean (± SD) concentrations of serum 25(OH)D and AMH were 37.8 (± 21.4) ng/ml and 1.6 (± 0.6) ng/ml, respectively. The proportion of study participants with serum vitamin D deficiency, insufficiency and sufficiency were 18.5%, 24.6%, and 56.9%, respectively. There was no statistically significant difference in the mean serum AMH among participants with deficient, insufficient, and sufficient vitamin D levels (1.41 ng/ml versus 1.56 ng/ml versus 1.59 ng/ml, P value = 0.539). Overall, there was no correlation between serum 25(OH)D, and serum AMH (r = 0.056, P > 0.05). Conclusion: Although the proportion of women with subnormal levels of serum vitamin D was relatively high, there was no association between serum levels of vitamin D and AMH.
尼日利亚绝经前妇女25-羟基维生素D与卵巢储备的关系
背景:尽管关于维生素D缺乏对绝经前妇女卵巢储备的潜在影响的知识越来越多,但在撒哈拉以南非洲的“高危”妇女中,这种疾病的负担明显很少。目的:了解尼日利亚绝经前妇女维生素D缺乏症的患病率,评估血清25-羟基维生素D [25(OH)D]与血清抗苗勒管激素(AMH)的关系。背景和设计:对在拉各斯一家三级医院就诊的218名尼日利亚绝经前妇女进行前瞻性横断面研究。材料和方法:采用ELIZA技术检测每位符合条件的受试者血清25(OH)D和AMH水平。统计学分析方法:采用Kruskal-Wallis检验和Pearson相关系数测定血清维生素D与血清AMH的关系。对211名数据完整的参与者进行数据分析。结果:血清25(OH)D和AMH的平均(±SD)浓度分别为37.8(±21.4)ng/ml和1.6(±0.6)ng/ml。血清维生素D缺乏、不足和充足的比例分别为18.5%、24.6%和56.9%。维生素D缺乏、不足和充足的参与者的平均血清AMH差异无统计学意义(1.41 ng/ml vs 1.56 ng/ml vs 1.59 ng/ml, P值= 0.539)。总体而言,血清25(OH)D与血清AMH无相关性(r = 0.056, P < 0.05)。结论:虽然血清维生素D水平低于正常的女性比例较高,但血清维生素D水平与AMH之间没有相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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