"BACTERIAL DIVERSITY OF THE GORGONIAN CORAL Plexaura sp.: SCREENING FOR ANTI-PATHOGENIC PROPERTY AGAINST NOSOCOMIAL PATHOGENIC Acinetobacter baumannii "

IF 0.6 0 ART

International Journal of Conservation Science Pub Date : 2023-03-15 DOI:10.36868/ijcs.2023.01.24

Stefanie Jessica Henny Larasati, A. Trianto, O. Radjasa, A. Sabdono

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引用次数: 1

Abstract

"Chronic infectious diseases caused by biofilm-forming pathogenic bacteria are the second rank causes of death in Indonesia after heart and blood vessel diseases. The emergence of antibiotic-resistant Acinetobacter baumannii pathogenic bacteria worldwide poses the main medicinal challenge to the search for new antibiotics. However, the use of marine invertebrates as raw material sources is not ecologically friendly due to the low concentration of bioactive compounds in marine invertebrates. This study aimed to investigate gorgonian Plexaura sp.-associated bacteria that have the potential as anti nosocomial pathogenic A. baumannii. A total of 29 gorgonian Plexaura sp.-associated bacterial isolates were screened for their antibacterial activity against nosocomial pathogenic A. baumannii. The 5 bacterial isolates exhibited antipathogenic activity against A. baumannii. The RA17-2 isolate showed the highest diameter size of the inhibition zone. The 16S rRNA sequence analyses revealed that these 5 isolates were closely related to Bacillus, Virgibacillus, and Nitratireductor. None of the 5 antipathogenic isolates possess PKS-I, PKS-II, and NRPS genes, except the PKS-I gene of the RA17-2 isolate. These results showed that Plexauridae sp is a potential source for the development of antibiotic drugs."

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柳珊瑚丛的细菌多样性:筛选抗医院致病性鲍曼不动杆菌

“在印度尼西亚，由形成生物膜的病原菌引起的慢性传染病是仅次于心脏和血管疾病的第二大死亡原因。全球范围内出现的具有抗生素耐药性的鲍曼不动杆菌病原菌对寻找新的抗生素构成了主要的医学挑战。然而，使用海洋无脊椎动物作为原料来源并不容易由于海洋无脊椎动物中的生物活性化合物浓度低，因此对生态友好。本研究旨在研究具有抗医院致病性鲍曼不动杆菌潜力的戈尔戈菌Plexaura sp.相关细菌。共筛选了29株与蛇床子Plexaura sp.相关的细菌分离株，以测定其对医院致病性鲍曼不动杆菌的抗菌活性。5株分离菌株对鲍曼不动杆菌具有抗病原活性。RA17-2分离物显示出抑制区的最大直径大小。16S rRNA序列分析表明，这5个分离株与芽孢杆菌、Virgibacillus和硝酸还原酶密切相关。除RA17-2分离株的PKS-I基因外，5个抗病菌株均不具有PKS-I、PKS-II和NRPS基因。这些结果表明Plexauridae sp是开发抗生素药物的潜在来源。“

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Conservation Science ART-

CiteScore

1.70

自引率

37.50%

发文量

审稿时长

10 weeks

期刊介绍： The International Journal of Conservation Science (IJCS) is a high quality peer-reviewed journal devoted to the publication of original research papers in applied conservation science and its broad range of applications. IJCS it is an open access journal. All content is freely available without charge to any user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. The topics cover all disciplines and branches of modern scientific conservation, including different aspects on general conservation theory, scientific investigation of works of art, authentication, determination of conservation state, compatibility studies for preservation and restoration procedures and monitoring of interventions effectiveness, etiopathology of historic and natural monuments, studies on the mechanisms of deterioration and degradation for different materials as structural and ornamental elements, impact of the environmental factors or agents on monuments and ecosystems, obtaining and characterization of new materials and procedures for preservation and restoration, new methodologies for scientific investigation, cross-related problems concerning research applied to conservation science, biodiversity conservation. Review articles in selected areas are published from time to time.