Cognitive Behavior Therapy Targeting Intolerance of Uncertainty Versus Selective Serotonin Reuptake Inhibitor for Generalized Anxiety Disorder: A Randomized Clinical Trial

IF 1.5 4区心理学 Q3 PSYCHOLOGY, CLINICAL

Behaviour Change Pub Date : 2021-09-01 DOI:10.1017/bec.2021.16

Mehdi Zemestani, Negar Beheshti, Farzin Rezaei, Colin van der Heiden, P. Kendall

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引用次数: 13

Abstract

Given the high prevalence and adverse outcomes associated with generalized anxiety disorder (GAD), development and expansion of effective treatment modalities are important. The present study compared the effectiveness of cognitive behavior therapy targeting intolerance of uncertainty (CBT-IU) and selective serotonin reuptake inhibitors (SSRIs) for treating GAD. A total of 30 Iranian patients with GAD (Mage = 25.16 ± 6.73) were randomised to receive either CBT-IU (n = 15) or SSRI (n = 15). Measures included the Structured Clinical Interview for DSM-5 (SCID-5), Penn State Worry Questionnaire (PSWQ), Why Worry-II (WW-II), Intolerance of Uncertainty Scale (IUS), and Negative Problem Orientation Questionnaire (NPOQ). Repeated measures analysis of variance tested differential treatment outcomes. The results of intention-to-treat (ITT) analysis indicated that although both CBT-IU and SSRI were effective treatments for GAD, CBT-IU produced significantly better results than SSRI at post-treatment. This clinical trial provides preliminary cross-cultural support for the treatment of GAD using CBT-IU, with findings suggesting that this non-medication intervention reduces GAD symptoms.

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针对不确定性不耐受的认知行为疗法与选择性血清素再摄取抑制剂治疗广泛性焦虑障碍:一项随机临床试验

鉴于广泛性焦虑症（GAD）的高患病率和不良后果，开发和扩展有效的治疗模式很重要。本研究比较了针对不确定性不耐受的认知行为疗法（CBT-IU）和选择性血清素再摄取抑制剂（SSRIs）治疗GAD的有效性。共有30名伊朗GAD患者（Mage=25.16±6.73）被随机分配接受CBT-IU（n=15）或SSRI（n=15）。测量包括DSM-5结构化临床访谈（SCID-5）、宾夕法尼亚州立大学担忧问卷（PSWQ）、Why Worry II（WW-II）、不确定性不容忍量表（IUS）和消极问题定向问卷（NPOQ）。方差的重复测量分析检验了不同的治疗结果。意向治疗（ITT）分析的结果表明，尽管CBT-IU和SSRI都是GAD的有效治疗方法，但CBT-IU在治疗后的效果明显优于SSRI。该临床试验为使用CBT-IU治疗GAD提供了初步的跨文化支持，研究结果表明，这种非药物干预可以减轻GAD症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behaviour Change PSYCHOLOGY, CLINICAL-

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Behaviour Change is the journal of the Australian Association for Cognitive and Behavioural Therapy and has long been considered a leader in its field. It is a quarterly journal that publishes research involving the application of behavioural and cognitive-behavioural principles and techniques to the assessment and treatment of various problems. Features of Behaviour Change include: original empirical studies using either single subject or group comparison methodologies review articles case studies brief technical and clinical notes book reviews special issues dealing with particular topics in depth.