{"title":"The Inflammatory Effect of Epigenetic Factors and Modifications in Depressive Disorder: A Review.","authors":"Keming Qi, Yi Yu, Jiang Guan, Jiayuan Zhang, Wei Lu, Yicong Wei","doi":"10.2174/1871524922666220308144518","DOIUrl":null,"url":null,"abstract":"Background Depressive disorder is one of the most common mental diseases and has become one of the three major causes of disability worldwide. Although some of the pathological mechanisms have been analyzed, the corresponding drug therapy has only achieved about 30% of curative effects. However, the pathological mechanism of depression is very complex, and the relationship between its complicated pathological mechanisms is still elusive. In recent years, there is more and more evidence that environmental stress induces stable changes in gene expression through the epigenetic mechanism and plays a vital role in the pathogenesis of the disease. Among them, neuroinflammation was considered to be a key pathological mechanism. Objective To explore the relationship between epigenetic mechanism and neuroinflammation in the pathological process of depression. Methods In this paper, we review the crucial role of neuroinflammation in complex pathological mechanisms, especially its complex interrelationship with neurotransmitters, neuroendocrine, neurogenesis, and neuronal plasticity, which play a key role in the pathology of depression. Results The relationship between epigenetic mechanism and neuroinflammation in the pathological process of depression was discussed, which mainly involves histone acetylation, histone methylation, DNA methylation, and non-coding RNA association. Conclusion This review will help to understand the role of epigenetic mechanisms in depression and its related inflammatory responses and provides direction and guidance for future research.","PeriodicalId":9799,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central nervous system agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871524922666220308144518","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Psychology","Score":null,"Total":0}
引用次数: 0
Abstract
Background Depressive disorder is one of the most common mental diseases and has become one of the three major causes of disability worldwide. Although some of the pathological mechanisms have been analyzed, the corresponding drug therapy has only achieved about 30% of curative effects. However, the pathological mechanism of depression is very complex, and the relationship between its complicated pathological mechanisms is still elusive. In recent years, there is more and more evidence that environmental stress induces stable changes in gene expression through the epigenetic mechanism and plays a vital role in the pathogenesis of the disease. Among them, neuroinflammation was considered to be a key pathological mechanism. Objective To explore the relationship between epigenetic mechanism and neuroinflammation in the pathological process of depression. Methods In this paper, we review the crucial role of neuroinflammation in complex pathological mechanisms, especially its complex interrelationship with neurotransmitters, neuroendocrine, neurogenesis, and neuronal plasticity, which play a key role in the pathology of depression. Results The relationship between epigenetic mechanism and neuroinflammation in the pathological process of depression was discussed, which mainly involves histone acetylation, histone methylation, DNA methylation, and non-coding RNA association. Conclusion This review will help to understand the role of epigenetic mechanisms in depression and its related inflammatory responses and provides direction and guidance for future research.
期刊介绍:
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.