Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases

IF 0.7 4区 物理与天体物理 Q4 CHEMISTRY, INORGANIC & NUCLEAR
Nukleonika Pub Date : 2021-11-25 DOI:10.2478/nuka-2021-0024
Patrycja Śliż-Szpytma, M. Lankosz, J. Dudała, D. Adamek, E. Radwańska, B. Kwinta, M. Jakšić, I. Božičević Mihalić, G. Provatas
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引用次数: 0

Abstract

Abstract Various types of neuromuscular diseases differ in symptoms, pathology, and clinical picture but one of their common elements is muscle weakness, which could lead to human motor activities impairment and in many cases to shortening of life span and even death due to respiratory failure. That is why it is very important to better understand the underlying causes of these diseases to be able to implement new methods of treatment more effectively. This paper presents the results of the elemental analysis of human muscular tissues affected by dystrophy and myopathy. For this purpose, the particle-induced X-ray emission method was used, which is perfectly suited for measuring light elements. The samples were analysed for differences in the elemental composition of Na, Mg, P, S, Cl, K, Fe, Zn, and Br. The results were presented in the form of elemental concentration maps and a thorough statistical analysis of the obtained data using the advanced statistical methods.
受神经肌肉疾病影响的人体肌肉组织亚细胞元素成像
摘要各种类型的神经肌肉疾病在症状、病理和临床表现上各不相同,但它们的共同因素之一是肌肉无力,这可能导致人类运动活动障碍,在许多情况下会缩短寿命,甚至因呼吸衰竭而死亡。这就是为什么更好地了解这些疾病的根本原因,以便能够更有效地实施新的治疗方法是非常重要的。本文介绍了对营养不良和肌病患者肌肉组织的元素分析结果。为此,使用了粒子诱导X射线发射方法,该方法非常适合测量轻元素。分析了样品中Na、Mg、P、S、Cl、K、Fe、Zn和Br元素组成的差异。结果以元素浓度图的形式呈现,并使用先进的统计方法对所获得的数据进行了全面的统计分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nukleonika
Nukleonika 物理-无机化学与核化学
CiteScore
2.00
自引率
0.00%
发文量
5
审稿时长
4-8 weeks
期刊介绍: "Nukleonika" is an international peer-reviewed, scientific journal publishing original top quality papers on fundamental, experimental, applied and theoretical aspects of nuclear sciences. The fields of research include: radiochemistry, radiation measurements, application of radionuclides in various branches of science and technology, chemistry of f-block elements, radiation chemistry, radiation physics, activation analysis, nuclear medicine, radiobiology, radiation safety, nuclear industrial electronics, environmental protection, radioactive wastes, nuclear technologies in material and process engineering, radioisotope diagnostic methods of engineering objects, nuclear physics, nuclear reactors and nuclear power, reactor physics, nuclear safety, fuel cycle, reactor calculations, nuclear chemical engineering, nuclear fusion, plasma physics etc.
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