Research progresses in the pathogenesis of multiple myeloma with extramedullary disease

国际输血及血液学杂志 Pub Date : 2019-05-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.03.006

Jiasi Zhang

引用次数: 0

Abstract

Multiple myeloma (MM) is a plasma cell malignant disease which is characterized by unlimited proliferation of monoclonal plasma cells and multiple infiltration of the bone marrow. Extramedullary myeloma (EMM) is found in some MM patients with extramedullary disease (EMD) at the initial diagnosis or during treatment. Particularly the hematogenous EMM has great heterogeneity and possesses poor prognosis in clinical applications. In general, the mechanism of EMM is closely related to cytogenetic abnormalities, the changes of the adhesion molecules, chemokine receptors, abnormal cytokine expression and exosomes etc. in bone marrow microenvironment. The authors focuses on the pathogenesis of EMM, in order to explore the causes of EMM heterogeneity. Key words: Multiple myeloma; Neoplasm metastasis; Plasmacytoma; Extramedullary myeloma; Hematogenous metastasis; Pathogenesis

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多发性骨髓瘤伴髓外病变发病机制的研究进展

多发性骨髓瘤（MM）是一种浆细胞恶性疾病，其特征是单克隆浆细胞的无限增殖和骨髓的多次浸润。骨髓外骨髓瘤（EMM）是在一些骨髓外疾病（EMD）的MM患者的最初诊断或治疗过程中发现的。尤其是血行EMM在临床应用中具有很大的异质性，预后较差。总的来说，EMM的机制与细胞遗传学异常、骨髓微环境中粘附分子、趋化因子受体、细胞因子表达异常和外泌体等的变化密切相关。作者着重探讨EMM的发病机制，以探讨EMM异质性的原因。关键词：多发性骨髓瘤；肿瘤转移；浆细胞瘤；髓外骨髓瘤；血源性转移；发病机制

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.