Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery in Stage 1B2 Cervical Cancer

Abstract

In 2020 we published a series of 18 patients who underwent neoadjuvant chemotherapy (NACT) and vaginal radical trachelectomy (VRT) as a fertility sparing alternative in stage 1B2 cervical cancer [1]. We concluded that this could be a safe fertility-sparing option in a selected group of women with stage 1B2 cervical cancer. We found a recurrence rate of 21% (three patients). All these patients had adenocarcinoma, lymphovascular space invasion (LVSI) present and a partial response to NACT. In our cohort in 78% of the women who were eligible fertility preservation was achieved. In this overview we provide an update of the data including an additional number of patients who have received this treatment in the meantime. Finally, we give advice about options for fertility sparing surgery.