Herbal Components for the Treatment of Alzheimer's Disease

IF 0.7 Q4 CHEMISTRY, MEDICINAL
Sonali Sundram, Tanu Bisht, R. Malviya, Akanksha Pandey
{"title":"Herbal Components for the Treatment of Alzheimer's Disease","authors":"Sonali Sundram, Tanu Bisht, R. Malviya, Akanksha Pandey","doi":"10.2174/2210315513666230123111541","DOIUrl":null,"url":null,"abstract":"\n\nGlobally, there are around 50 million Alzheimer's disease sufferers worldwide, a number that is expected to double every five years and reach 152 million by 2050. Traditional drugs for cognitive impairment are only palliative and do not cure the disease. Alzheimer's disease is characterised by memory and language loss, as well as difficulties with visual orientation and greater executive function.\n\n\n\nThe present study aimed to examine various causes, mechanisms, and roles of different herbal components in the treatment of Alzheimer’s disease.\n\n\n\nSince ancient times, several different plants have been utilised to improve memory and treat various dementia-related issues. These anti-AD plants include a wide taxonomic range due to acetyl choline esterase inhibition, antioxidant capacity, neuroprotection, mitochondrial energy restoration, and/or precipitated protein clearance. Secondary metabolites of these medicinal plants may be used to treat AD. AADvac1 is an active vaccination that stimulates an immune response by attacking numerous critical epitopes in pathogenic tau variants, thereby preventing tau aggregation and reducing the development of neurofibrillary tangles.\n\n\n\nHerbal plants are widely used because of their perceived effectiveness, safety, and low cost. To summarise, the evidence supporting the use of herbal components is promising, but more work is needed.\n","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2210315513666230123111541","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

Abstract

Globally, there are around 50 million Alzheimer's disease sufferers worldwide, a number that is expected to double every five years and reach 152 million by 2050. Traditional drugs for cognitive impairment are only palliative and do not cure the disease. Alzheimer's disease is characterised by memory and language loss, as well as difficulties with visual orientation and greater executive function. The present study aimed to examine various causes, mechanisms, and roles of different herbal components in the treatment of Alzheimer’s disease. Since ancient times, several different plants have been utilised to improve memory and treat various dementia-related issues. These anti-AD plants include a wide taxonomic range due to acetyl choline esterase inhibition, antioxidant capacity, neuroprotection, mitochondrial energy restoration, and/or precipitated protein clearance. Secondary metabolites of these medicinal plants may be used to treat AD. AADvac1 is an active vaccination that stimulates an immune response by attacking numerous critical epitopes in pathogenic tau variants, thereby preventing tau aggregation and reducing the development of neurofibrillary tangles. Herbal plants are widely used because of their perceived effectiveness, safety, and low cost. To summarise, the evidence supporting the use of herbal components is promising, but more work is needed.
治疗阿尔茨海默病的草药成分
在全球范围内,全球约有5000万阿尔茨海默病患者,预计这个数字每五年翻一番,到2050年将达到1.52亿。治疗认知障碍的传统药物只能缓解症状,不能治愈疾病。阿尔茨海默病的特点是记忆力和语言丧失,视觉定向困难和执行功能增强。本研究旨在探讨不同草药成分治疗阿尔茨海默病的各种原因、机制和作用。自古以来,几种不同的植物被用来改善记忆和治疗各种与痴呆症相关的问题。由于乙酰胆碱酯酶抑制、抗氧化能力、神经保护、线粒体能量恢复和/或沉淀蛋白清除,这些抗AD植物包括广泛的分类范围。这些药用植物的次级代谢产物可用于治疗AD。AADvac1是一种主动疫苗接种,通过攻击致病性tau变体中的许多关键表位来刺激免疫反应,从而防止tau聚集并减少神经原纤维缠结的发展。草本植物因其有效性、安全性和低成本而被广泛使用。总之,支持使用草药成分的证据是有希望的,但还需要更多的工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Natural Products Journal
Natural Products Journal CHEMISTRY, MEDICINAL-
CiteScore
1.70
自引率
0.00%
发文量
91
期刊介绍: The Natural Products Journal a peer reviewed journal, aims to publish all the latest and outstanding developments in natural products. The Natural Products Journal publishes original research articles, full-length/mini reviews, letters and guest edited issues on all aspects of research and development in the field including: isolation, purification, structure elucidation, synthesis and bioactivity of chemical compounds found in nature.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信