Rapid Desensitization after a Type I Hypersensitivity Reaction to Ceftazidime/ Avibactam.

Abstract

Background Frequent antibiotic use increases the risk of multidrug-resistant pathogen formation and hypersensitivity to antibiotics, including Type I hypersensitivity reactions. Presentation We present a case of the first successful induction of tolerance procedure for the antibiotic ceftazidime/ avibactam. The patient developed immediate generalized urticaria and flushing on his first dose of ceftazidime/avibactam. He was able to tolerate a 12-step desensitization procedure that resulted in the clearance of his infection. Conclusions Drug desensitization procedures are useful for patients with adverse drug reactions in which optimal alternatives are not available. This is the first case report demonstrating a successful rapid induction of tolerance for the antibiotic ceftazidime/avibactam.