Calcium phosphate cements comprising spherical porous calcium phosphate granules: synthesis, structure, and properties

IF 2.2 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

Journal of Asian Ceramic Societies Pub Date : 2022-09-16 DOI:10.1080/21870764.2022.2123514

M. Kamitakahara, Kanau Asahara, H. Matsubara

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引用次数: 1

Abstract

ABSTRACT Calcium phosphate cements (CPCs) are used as artificial bone materials. The bone regeneration ability of CPCs can be improved by controlling their composition, porosity, and pore size. This study aims to design novel CPCs with high bone regeneration ability by controlling their microstructure. CPCs with macropores and micropores were prepared by incorporating spherical porous calcium phosphate granules composed of rod-shaped, calcium-deficient hydroxyapatite (CDHA) or plate-shaped octacalcium phosphate (OCP) particles. The granules were mixed with a binder (cement powder) composed primarily of α-tricalcium phosphate. The structure, morphology, compressive strength, porosity, specific surface area, pore size distribution, dissolution characteristics, and effects on cell viabilities were studied for the synthesized samples. The CPCs composed of porous granules had high porosity (~80%) and both macropores and micropores, which are expected to contribute to bone regeneration. The CPCs composed of porous granules showed a smaller specific surface area but a larger dissolution rate than the granule-free samples. The CPC composed of OCP granules showed a higher dissolution rate than the CPCs containing CDHA granules. In the cell culture experiments, the preosteoblasts proliferated on the CPCs, indicating that these CPCs could function as scaffolds for bone regeneration. Graphical Abstract

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球形多孔磷酸钙颗粒磷酸钙水泥的合成、结构和性能

摘要磷酸钙骨水泥是一种人工骨材料。CPC的骨再生能力可以通过控制其组成、孔隙率和孔径来提高。本研究旨在通过控制其微观结构来设计具有高骨再生能力的新型CPC。通过掺入由杆状缺钙羟基磷灰石（CDHA）或板状磷酸八钙（OCP）颗粒组成的球形多孔磷酸钙颗粒，制备了具有大孔和微孔的CPC。将颗粒与主要由α-磷酸三钙组成的粘合剂（水泥粉）混合。研究了合成样品的结构、形貌、抗压强度、孔隙率、比表面积、孔径分布、溶解特性以及对细胞活力的影响。由多孔颗粒组成的CPC具有高孔隙率（~80%），同时具有大孔和微孔，有望有助于骨再生。由多孔颗粒组成的CPC显示出比表面积较小但溶解速率大于无颗粒样品。由OCP颗粒组成的CPC显示出比含有CDHA颗粒的CPC更高的溶解速率。在细胞培养实验中，前成骨细胞在CPC上增殖，表明这些CPC可以作为骨再生的支架。图形摘要

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来源期刊

Journal of Asian Ceramic Societies Materials Science-Ceramics and Composites

CiteScore

5.00

自引率

4.30%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Asian Ceramic Societies is an open access journal publishing papers documenting original research and reviews covering all aspects of science and technology of Ceramics, Glasses, Composites, and related materials. These papers include experimental and theoretical aspects emphasizing basic science, processing, microstructure, characteristics, and functionality of ceramic materials. The journal publishes high quality full papers, letters for rapid publication, and in-depth review articles. All papers are subjected to a fair peer-review process.