COVID-19 therapy approaches and vaccine development: the role of nanotechnology

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
Maham Doagooyan, S. Alavizadeh, S. Gheibi-Hayat, Arad Boustan, F. Gheybi
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引用次数: 3

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) caused an outbreak in Wuhan, China in December 2019, and right after that SARS-COV-2 spreads around the world infecting millions of people worldwide. This virus belongs to wide range virus family and cause moderate to severe signs in patients, the Sars-COV-2, can spread faster than others between humans and leads to severe outbreak. Recently researchers succeed to develop various vaccines including inactivated or attenuated viral vaccines as well as subunit vaccines to prevent SARS-COV-2 infection. Nanotechnology is advantageous for the design of vaccines since nano scale materials could benefit the delivery of antigens, and could be used as adjuvants to potentiate the response to the vaccines. Indeed, among various vaccines entered clinical trials, there are mRNA-based vaccine designed based on lipid nanoparticles. Herein, we summarized SARS-COV-2 structure, pathogenesis, therapeutic approaches and some COVID-19 vaccine candidates and highlighted the role of nanotechnology in developing vaccines against SARS-Cov-2 virus.
COVID-19治疗方法和疫苗开发:纳米技术的作用
2019年12月,严重急性呼吸综合征冠状病毒2 (SARS-COV-2)在中国武汉爆发,随后SARS-COV-2在全球传播,感染了全球数百万人。这种病毒属于广泛的病毒家族,在患者中引起中度至重度症状,Sars-COV-2可以比其他病毒更快地在人与人之间传播,并导致严重的疫情。最近,为了预防SARS-COV-2感染,研究人员成功开发了灭活疫苗、减毒疫苗和亚单位疫苗等多种疫苗。纳米技术对疫苗的设计是有利的,因为纳米级材料可以有利于抗原的递送,并且可以用作佐剂来增强对疫苗的反应。事实上,在进入临床试验的各种疫苗中,有基于脂质纳米颗粒设计的基于mrna的疫苗。本文综述了SARS-COV-2的结构、发病机制、治疗方法和一些候选疫苗,并重点介绍了纳米技术在研制SARS-COV-2病毒疫苗中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
自引率
0.00%
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0
审稿时长
12 weeks
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