"Electronic nose" signals correlation evaluation for nasal mucus and exhaled breath condensate of calves with the clinical and laboratory indicators

Abstract

In this article the “electronic nose” system (SNT LLC, Russia) with an array of 8 differently selective piezoelectric sensors (nanobio array) was used to assess the health and functioning of the respiratory organs in young cattle by the fraction of volatile compounds over bioassays (exhaled breath condensate and nasal mucus). The sorption of the volatile fraction of substances vapors from the two types of bioassays was studied for 80s with the frontal effortless injection of vapors into the near-sensor space of the detection cell of the “electronic nose” at 20 ± 1 oC with the subsequent fixation of the spontaneous desorption for 120s - total measurement time 200s . The simplest analytical signals of the "electronic nose" ( S S и S neg ) recorded and calculated in the software for the samples were proposed suitable for assessing the health of the respiratory organs in calves. A significant correlation was found between the analytical signals of the “electronic nose” and the established informative indicators of bovine respiratory diseases: increased activity of aspartate aminotransferase, alanine aminotransferase, creatinine in samples of exhaled breath condensate, respiratory failure index, and leukocyte count. The samples of nasal mucus were better used for the health assessment of the respiratory system using the nanobio array of sensors. Despite the initial small number of samples, the approach is universal and could be extended to the studies of other animals. Key words : piezosensors, “electronic nose”, correlation coefficient, nasal mucus, exhaled breath condensate, diagnosis, bovine respiratory disease, markers of inflammation (Russian)  DOI: http://dx.doi.org/10.15826/analitika.2019.23.4.014 T.A. Kuchmenko, A.A. Shuba 1 , R.U. Umarkhanov 1 , A.E. Chernitskii 2 1 Voronezh State University of Engineering Technologies”, pr. Revolutsii, 19, Voronezh, 394000, Russian Federation 2 All-Russian Scientific Research Veterinary Institute of Pathology, Pharmacology and Therapy, Research Center of Clinical Pharmacology and Therapy, Quality and Safety of Raw Materials and Products, st. Lomonosova, 114b, Voronezh, Russian Federation