Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults

Q3 Medicine

Nutrition and Healthy Aging Pub Date : 2019-09-23 DOI:10.3233/NHA-180056

G. F. Dodd, C. Williams, L. Butler, J. Spencer

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引用次数: 25

Abstract

BACKGROUND: Consumption of flavonoids, natural compounds found in foods such as berries and cocoa, have been shown to be beneficial for cognitive function. However, less is known about potential mechanisms and acute benefits for the older population. OBJECTIVE: To determine whether acute intake of flavonoid-rich blueberry could have beneficial effects on cognitive function in a sample of healthy older adults and identify possible mechanisms. METHODS: A cross-over randomised controlled trial (RCT) was conducted (N = 18) with volunteers receiving a flavonoid-rich blueberry beverage (579mg of antho- and pro-cyanidins) on one visit and a sugar-matched control on another. Cognitive function was measured at baseline, 2 and 5 hours post consumption of the intervention and blood pressure (BP), arterial stiffness and plasma brain-derived neurotrophic factor (BDNF) concentration at baseline and an hour post-intervention. RESULTS: Whilst there was no significant effect of the intervention on global cognitive function, performance was significantly different at 2 compared to 5 hours following the control beverage (p 0.05). CONCLUSIONS: A single dose of flavonoid-rich blueberry could have a potentially protective effect on cognitive function in healthy older adults, possibly due to improved cerebrovascular function and positive interactions with cell signalling pathways involved in cognitive processes.

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富含类黄酮的蓝莓对健康老年人认知和血管功能的急性影响

背景:食用类黄酮，一种在浆果和可可等食物中发现的天然化合物，已被证明对认知功能有益。然而，对老年人群的潜在机制和急性益处知之甚少。目的:确定急性摄入富含类黄酮的蓝莓是否对健康老年人的认知功能有有益的影响，并确定可能的机制。方法:进行了一项交叉随机对照试验(RCT) (N = 18)，志愿者在一次访问中接受富含类黄酮的蓝莓饮料(579毫克花青素和前花青素)，在另一次访问中接受糖匹配的对照。在基线、干预后2小时和5小时测量认知功能，在基线和干预后1小时测量血压(BP)、动脉僵硬度和血浆脑源性神经营养因子(BDNF)浓度。结果:虽然干预对整体认知功能没有显著影响，但在对照饮料后2小时与5小时的表现有显著差异(p < 0.05)。结论:单剂量富含类黄酮的蓝莓可能对健康老年人的认知功能有潜在的保护作用，可能是由于改善脑血管功能和与参与认知过程的细胞信号通路的积极相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Healthy Aging Agricultural and Biological Sciences-Food Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.