{"title":"An overview of a biopsychosocial model of epigenetics and pain catastrophizing","authors":"Danielle M. Brecht, Robert J. Gatchel","doi":"10.1111/jabr.12171","DOIUrl":null,"url":null,"abstract":"<p>In an earlier Special Issue in the <i>Journal of Applied Biobehavioral Research</i> (JABR), Gatchel (<i>Journal of Applied Biobehavioral Research</i>, 2017, 22[1], e12088) addressed the construct of pain catastrophizing (PC). The present article is meant to extend those reviews within a biopsychosocial context, as well as update recent research on PC with a specific concentration on genetic factors. An overview of biological factors as they relate to PC and epigenetics are reviewed first (brain areas associated with pain and how they adapt neurochemically to chronic noxious stimuli, polymorphism of various genes, etc.), proceeded by the discussion of psychological (depression, anxiety, and the genomic link to neuroticism) and social influences (reason people engage in PC, age's impact on neuronal restructuring) as they corroborate the argument of PC's link to genetic factors. Finally, this article concludes by providing future directions for research concerning PC such as examining the efficacy of Pain Neurobiology Education, as well as gene therapy.</p>","PeriodicalId":45868,"journal":{"name":"JOURNAL OF APPLIED BIOBEHAVIORAL RESEARCH","volume":"24 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jabr.12171","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF APPLIED BIOBEHAVIORAL RESEARCH","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jabr.12171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Social Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
In an earlier Special Issue in the Journal of Applied Biobehavioral Research (JABR), Gatchel (Journal of Applied Biobehavioral Research, 2017, 22[1], e12088) addressed the construct of pain catastrophizing (PC). The present article is meant to extend those reviews within a biopsychosocial context, as well as update recent research on PC with a specific concentration on genetic factors. An overview of biological factors as they relate to PC and epigenetics are reviewed first (brain areas associated with pain and how they adapt neurochemically to chronic noxious stimuli, polymorphism of various genes, etc.), proceeded by the discussion of psychological (depression, anxiety, and the genomic link to neuroticism) and social influences (reason people engage in PC, age's impact on neuronal restructuring) as they corroborate the argument of PC's link to genetic factors. Finally, this article concludes by providing future directions for research concerning PC such as examining the efficacy of Pain Neurobiology Education, as well as gene therapy.
期刊介绍：
The Journal of Applied Biobehavioral Research, launched in 1993, aims to disseminate findings of behavioral science research which have applications to current problems of society. By publishing relevant research and emphasizing the excellence of experimental design, as well as potential applicability of experimental results, the journal bridges the theoretical and applied areas of biobehavioral research. The Journal of Applied Biobehavioral Research serves as a means of communication among scientists, as well as between researchers and those engaged in the task of solving social and biomedical problems.
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