Preparation and Characterization of Curcumin Niosomal Nanoparticles via a Simple and Eco-friendly Route

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY

Journal of Nanostructures Pub Date : 2019-10-01 DOI:10.22052/JNS.2019.04.020

Zahra Zinatloo-Ajabshir, S. Zinatloo-Ajabshir

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引用次数: 31

Abstract

In this investigation, curcumin niosomal nanoparticles were prepared via a simple, efficient and eco-friendly route, thin film hydration (TFH), in the presence of different mixture of the surfactants (tween 60 and span 60). Cholesterol ratio to surfactant, as effective factor, was altered to obtain the optimal nanoparticles. The size, zeta potential, size distribution, entrapment efficiency of the prepared nanoparticles were examined and compared. The optimum nanoparticles were chosen to examine the release from the dialysis membrane. Ratio of cholesterol to surfactant was found to have key and notable influence on the size, zeta potential, size distribution, entrapment efficiency of the prepared nanoparticles. The nanoparticles prepared with Formulations 3 and 5 as optimum nanoparticles were chosen to examine the release from the dialysis membrane. The results denoted that by increasing the ratio of cholesterol to surfactant, the rate of curcumin release was enhanced from the membrane. High quantities of cholesterol in the formulation 3, in addition to explosive release, can lead to slow release.

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简单环保法制备姜黄素纳米粒子及其表征

在不同表面活性剂(tween 60和span 60)的混合物存在下，采用薄膜水合(TFH)这一简单、高效、环保的方法制备了姜黄素纳米粒子。以胆固醇与表面活性剂的比值为影响因素，得到了最佳的纳米颗粒。对制备的纳米颗粒的粒径、zeta电位、粒径分布、包封效率进行了考察和比较。选择最佳的纳米颗粒，考察透析膜的释放情况。结果表明，表面活性剂与胆固醇的配比对纳米颗粒的粒径、zeta电位、粒径分布和包封效率有重要影响。选择配方3和5制备的纳米颗粒作为最佳纳米颗粒，考察其从透析膜上的释放。结果表明，通过增加胆固醇与表面活性剂的比例，姜黄素从膜上的释放速度加快。制剂中胆固醇含量高，除了爆炸性释放外，还会导致缓慢释放。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nanostructures NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.