Type I cryoglobulinemia related to Sjögren’s syndrome and MGUS: a case report

Abstract

Cryoglobulinemia is a rare disease caused by the specific antibodies which precipitate at low temperatures being present within the blood serum. It is observed in the course of disorders such as autoimmune diseases, lymphoproliferative neoplasms, and infectious diseases — mainly HCV infections. Three types of cryoglobulinemia have been identified, differing in the type of immunoglobulins involved and symptoms being manifested. We are presenting a case of a 61-year-old female patient with type I cryoglobulinemia related to Sjogren’s syndrome and complicated by monoclonal gammopathy of undetermined significance.