Research progress on the prevention and treatment of radiation-induced intestinal injury by the genus Lactobacillus

中华放射肿瘤学杂志 Pub Date : 2020-04-15 DOI:10.3760/CMA.J.CN113030-20191108-00013

T. Zhao, Yongqiang Yang, S. Cai, Ye Tian

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Abstract

Acute radiation-induced intestinal injury is the common complication in patients following abdominal and pelvic radiotherapy. However, no effective clinical prevention and treatment interventions are available. As the probiotics and symbiotic bacteria, many species of the genus Lactobacillus are normally present in the gastrointestinal tract and beneficial for the intestinal health. Preclinical studies have reported that the genus Lactobacillus can prevent and treat acute radiation-induced intestinal injury by protecting crypt stem cells, maintaining intestinal barrier and exerting the antioxidant effect, etc. Clinical trials have prompted that oral administration of adequate complex probiotics containing Lactobacillus spp.at one week before radiotherapy contributes to preventing radiation-induced diarrhea. In addition, oral intake of the genus Lactobacillus has the tendency to treat radiation-induced diarrhea and mitigate acute radiation proctitis. At present, no relevant adverse events have been reported. Key words: Genus Lactobacillus; Aacute radiation-induced intestinal injury; Research progress

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乳杆菌属预防和治疗辐射性肠道损伤的研究进展

急性放射性肠损伤是腹盆腔放射治疗后常见的并发症。然而，目前尚无有效的临床预防和治疗措施。作为益生菌和共生菌，乳杆菌属的许多种通常存在于胃肠道中，对肠道健康有益。临床前研究报道，乳杆菌属通过保护隐窝干细胞、维持肠道屏障、发挥抗氧化作用等，预防和治疗急性辐射引起的肠道损伤。临床试验表明，在放疗前一周口服足够的含有乳酸杆菌的复合益生菌有助于预防辐射引起的腹泻。此外，口服乳杆菌属具有治疗放射性腹泻和减轻急性放射性直肠炎的倾向。目前未见相关不良事件的报道。关键词:乳杆菌属;急性放射性肠损伤;研究进展

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来源期刊

中华放射肿瘤学杂志

自引率

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发文量

6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.