Study on Apoptosis of Squamous Cell Carcinoma Using Photothermal Therapy with Partial Injection of Gold Nanoparticles

IF 2.7 3区工程技术 Q2 ENGINEERING, MECHANICAL

Nanoscale and Microscale Thermophysical Engineering Pub Date : 2023-06-04 DOI:10.1080/15567265.2023.2220769

Donghyuk Kim, Hyunju Kim

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引用次数: 0

Abstract

ABSTRACT Recently, the incidence of skin cancer has been increasing owing to the development of science and technology and the increase in outdoor activities. Research on photothermal therapy as a treatment technique for similar skin cancer is in progress. Photothermal therapy is a treatment technique that removes tumor tissue by increasing the temperature. It has the advantage of rapid recovery and a low risk of secondary infection. In this study, a numerical investigation of photothermal therapy based on heat transfer is conducted on squamous cell carcinoma present inside the skin layer. Analysis is performed by varying the number of injections of gold nanoparticles, volume fraction of gold nanoparticles in the tumor, and laser intensity. In addition, conditions for maximizing expression of apoptosis in the tumor and minimizing amount of thermal damage to surrounding normal tissues are identified through the variable which is apoptosis retention ratio, thermal hazard value and effective apoptosis retention ratio. It was confirmed that the optimal therapeutic effect was shown when the volume fraction of injected GNPs was 10−3, the number of injections was 6 times, and the irradiated laser intensity was 140 mW for the tumor presented in this study. Ultimately, these results are expected to accelerate the commercialization of photothermal therapy.

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部分注射金纳米颗粒光热治疗鳞状细胞癌细胞凋亡的研究

近年来，由于科学技术的发展和户外活动的增加，皮肤癌的发病率不断上升。光热疗法作为一种治疗类似皮肤癌的技术正在研究中。光热疗法是一种通过提高温度来去除肿瘤组织的治疗技术。它具有恢复快、继发感染风险低的优点。在本研究中，基于传热的光热疗法对存在于皮肤层内的鳞状细胞癌进行了数值研究。通过改变金纳米颗粒的注射次数、肿瘤中金纳米颗粒的体积分数和激光强度来进行分析。此外，通过细胞凋亡保留比、热危害值和有效细胞凋亡保留比这一变量，确定细胞凋亡在肿瘤中表达最大化和对周围正常组织热损伤最小的条件。研究证实，对于本研究的肿瘤，当注射GNPs的体积分数为10−3，注射次数为6次，照射激光强度为140 mW时，治疗效果最佳。最终，这些结果有望加速光热疗法的商业化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanoscale and Microscale Thermophysical Engineering 工程技术-材料科学：表征与测试

CiteScore

5.90

自引率

2.40%

发文量

审稿时长

3.3 months

期刊介绍： Nanoscale and Microscale Thermophysical Engineering is a journal covering the basic science and engineering of nanoscale and microscale energy and mass transport, conversion, and storage processes. In addition, the journal addresses the uses of these principles for device and system applications in the fields of energy, environment, information, medicine, and transportation. The journal publishes both original research articles and reviews of historical accounts, latest progresses, and future directions in this rapidly advancing field. Papers deal with such topics as: transport and interactions of electrons, phonons, photons, and spins in solids, interfacial energy transport and phase change processes, microscale and nanoscale fluid and mass transport and chemical reaction, molecular-level energy transport, storage, conversion, reaction, and phase transition, near field thermal radiation and plasmonic effects, ultrafast and high spatial resolution measurements, multi length and time scale modeling and computations, processing of nanostructured materials, including composites, micro and nanoscale manufacturing, energy conversion and storage devices and systems, thermal management devices and systems, microfluidic and nanofluidic devices and systems, molecular analysis devices and systems.