Cytotoxic Constituents from the Rhizomes of Monstera deliciosa

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-08-20 DOI:10.25135/rnp.352.2203.2390

Fathy A. Behery, Marwa Elsbaey, Kadria F. Ahmad, M. Amer, M. Lahloub

引用次数: 1

Abstract

: A phytochemical study of the rhizomes of Monstera deliciosa has led to isolation of fourteen compounds ( 1 - 14 ) for the first time from the plant species. The structure elucidation was carried out using 1D and 2D NMR data. The cytotoxic activities of the compounds against the liver (HepG-2), larynx (Hep-2), colon (HCT-116), and breast (MCF-7) cancer cell lines were evaluated using MTT assay. Syringaresinol ( 6 ) showed remarkable IC 50 values against the four tested cell lines. In addition, 9, 12, 13-trihydroxy-10-octadecenoic acid ( 14 ) was highly cytotoxic against Hep-2 and HCT-116 cell lines.

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美味夜蛾根状茎的细胞毒性成分

摘要:对香豆根状茎进行了植物化学研究，首次从该植物中分离到14个化合物(1 ~ 14)。利用一维和二维核磁共振数据进行了结构解析。采用MTT法测定化合物对肝癌(HepG-2)、喉癌(Hep-2)、结肠癌(HCT-116)和乳腺癌(MCF-7)细胞系的细胞毒活性。丁香皂苷醇(6)对四种被试细胞系的ic50值显著。此外，9,12,13 -三羟基-10-十八烯酸(14)对Hep-2和HCT-116细胞系具有高度的细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.