Physiological role of aldosterone in pregnancy, importance of correction in pathological conditions. What is known about pharmacological targets

Abstract

Aldosterone is the main mineralocorticosteroid hormone of the human adrenal cortex. It plays a key role in the regulation of kidney and cardiovascular function. Its role especially increases in the adaptation of the woman’s body during pregnancy, and consists in maintaining the balance of electrolytes, blood pressure, ensuring sufficient trophoblast invasion and adequate placental perfusion. This article describes the mechanism of synthesis and action of aldosterone, its biological role and place in the structure of the renin-angiotensin-aldosterone system (RAAS). A special place is given to aldosterone in maintaining hemodynamics during physiological pregnancy, and to violations of the RAAS, as a key to understanding the links in the pathogenesis of preeclampsia.