The Role of Certain Polymorphic Variants in Genes, Previously Associated with Blood Pressure Values, with Reference to the Risk of Development of Coronary Artery Disease

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2022-12-01 DOI:10.2478/amb-2022-0034

T. Yaneva-Sirakova, R. Kaneva, R. Tzveova, R. Bozhilova, I. Popov, M. Shumkova, I. Hristova, D. Vassilev

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引用次数: 0

Abstract

Abstract The aim of the study was to analyze the effect of polymorphic variants previously associated with arterial hypertension (AH) in Genome Wide Association Studies (GWASs) in/next to genes and locuses CYP7A1 and PLEKHA7 on the development of coronary artery disease (CAD) in Bulgarian patients. A hundred and nine consecutive patients with angiographically documented CAD were studied. The genotyping was done with 7900 HT Fast Real-Time PCR (Applied Biosystems) with TaqMan® method. The control group consisted of 192 healthy population controls, selected from the bio- bank of the Molecular Medicine Center. SPSS and PLINK were used for the statistical analysis with level of significance < 0.05 and confidence interval 95%. The mean age of the studied patients was 63.71 ± 9.35 years; 35 (35%) females. Previous myocardial infarction (MI) had 38(38%); one-vessel – 39 (39%); two-vessel – 28 (28%); three-vessel disease – 34 (34%); 43 (43%) were with diabetes mellitus; 92 (92%) – with arterial hypertension (AH); 77 (77%) – with dyslipidemia; 42 (42%) were smokers; 25 (25%) were obese. We did not find any significant association between CAD and poly- morphism rs11191548 near CYP17A1 and only a tendency for genotype of rs381815 in PLEKHA7 (p = 0.06; OR 0.64; CI 0.40-1.02 for CAD) under dominant model. This is of practical importance both for studying the genetic aspects of CAD in the future and for enlargement of the current database.

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先前与血压值相关的基因中某些多态性变异与冠状动脉疾病发展风险的作用

该研究的目的是分析基因组关联研究(GWASs)中先前与动脉高血压(AH)相关的基因和基因位点CYP7A1和PLEKHA7的多态性变异对保加利亚患者冠状动脉疾病(CAD)发展的影响。对109例连续的血管造影记录的冠心病患者进行了研究。采用TaqMan®方法，采用7900 HT Fast Real-Time PCR (Applied Biosystems)进行基因分型。对照组选取分子医学中心生物库192例健康人群作为对照。采用SPSS和PLINK进行统计学分析，显著性水平< 0.05，置信区间为95%。患者平均年龄为63.71±9.35岁;35名(35%)女性。既往心肌梗死38例(38%);单船39艘(39%);双船- 28 (28%);三支血管疾病34例(34%);糖尿病患者43例(43%);92例(92%)-患有动脉高血压(AH);77例(77%)-患有血脂异常;吸烟者42例(42%);25例(25%)为肥胖。我们没有发现CAD与CYP17A1附近的rs11191548多态性有任何显著的关联，仅在PLEKHA7中有rs381815基因型的倾向(p = 0.06;或0.64;CI为0.40-1.02 (CAD)。这对今后研究CAD的遗传方面和扩大现有数据库都具有实际意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.