Formulation and evaluation of polyherbal cream and lotion to treat psoriasis-induced secondary infections.

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics

Current clinical pharmacology Pub Date : 2019-10-17 DOI:10.2174/1574884714666191017111218

P. Joshi, Sushil Joshi, Urvashi Rajani, R. Semwal, D. Semwal

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引用次数: 3

Abstract

BACKGROUND Psoriasis is one of the most common skin diseases in human and affected a major population worldwide. Aim: The aim of the present study is to evaluate the efficacy of selected polyherbal formulations against psoriasis-induced secondary infections. Methods: Samples were collected from the scalp, behind the ears, chest and back of the patients. The microscopic examination of fungal and bacterial growth was carried out with lactophenol cotton blue stain and gram stain respectively. Volatile constituents of essential oils were identified by GC-MS analysis, in order to investigate the relation between chemical composition and biological activity. Nutrient agar media was used for antibacterial activity whereas Sabourauds dextrose agar media was used for antifungal activity. Results: A total of 24 isolates were obtained from 2 patient of scalp psoriasis. Anti-oxidant activity of the samples was determined using DPPH radical scavenging method. In the present study, EOs showed a good antifungal action against Malassezia pachydermatis and other microbial strains. The GC-MS analysis revealed the presence of eugenol, linalool, citral, neral, limonene, terpenes, eucalyptol and thymol in the essential oils. The formulated retention lotion 1 (L4), 2 (L5), 3 (L6) and cream 1 (C1) showed DPPH radical scavenging activity by 23.52%, 24.48%, 28% and 5.08%, respectively. Conclusion: The present study concluded that most of the formulated lotions and creams showed good antimicrobial activity and may be applied topically against scalp psoriasis.

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多羟基乳膏和洗剂治疗银屑病继发感染的配方和评价。

背景银屑病是人类最常见的皮肤病之一，影响着世界范围内的主要人群。目的：本研究的目的是评估选定的多羟基制剂对银屑病诱导的继发感染的疗效。方法：从患者的头皮、耳后、胸部和背部采集样本。分别用乳酚棉蓝染色和克氏染色对真菌和细菌的生长进行显微镜检查。采用气相色谱-质谱联用技术对挥发油的挥发性成分进行了鉴定，以探讨挥发油的化学组成与生物活性之间的关系。营养琼脂培养基用于抗菌活性，而Sabourauds葡萄糖琼脂培养基则用于抗真菌活性。结果：从2例头皮银屑病患者中分离得到24个分离株。采用DPPH自由基清除法测定了样品的抗氧化活性。在本研究中，EOs对厚皮马拉色菌和其他微生物菌株表现出良好的抗真菌作用。GC-MS分析表明，精油中存在丁香酚、芳樟醇、柠檬醛、总黄酮、柠檬烯、萜烯、桉树醇和百里酚。配制的保留洗剂1（L4）、2（L5）、3（L6）和乳膏1（C1）对DPPH自由基的清除活性分别为23.52%、24.48%、28%和5.08%。结论：本研究得出结论，大多数配方乳液和乳膏具有良好的抗菌活性，可用于头皮银屑病的局部治疗。

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来源期刊

Current clinical pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.