The role of remote ischemic preconditioning in preventing contrast-induced nephropathy following invasive coronary angiography; a randomized controlled trial

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2021-12-11 DOI:10.34172/jrip.2022.32000

Mohammadmehdi Peighanbari, Hoda Raffieijelodar, Z. Shafii

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引用次数: 0

Abstract

Introduction: Remote ischemic preconditioning (RIPC) is now proposed as an effective approach for preventing contrast-induced nephropathy (CIN); however, the results on its efficacy have already remained uncertain. Objectives: We aimed to assess the beneficial effects of RIPC in preventing CIN in patients undergoing coronary angiography (CA) followed by angioplasty. Patients and Methods: One hundred patients candidate for elective CA and coronary angioplasty, moderate to high risk for CIN were randomized into two groups including the group which planned for RIPC, and the control group. The overall prevalence rate of CIN was assessed and compared across the two groups. Results: The two groups were matched for demographics, cardiovascular risk profiles and laboratory parameters. The prevalence of CIN in RIPC group was 14.0% and in the control group was 26.0% indicating no statistical difference between the two groups (P = 0.105). Requiring dialysis was also planned for 0.0% and 2.0% respectively with no difference (P = 0.500). Conclusion: RIPC may not prevent CIN in patients who are candidate for invasive CA. Trial Registration: The study was approved in the Iranian Registry of Clinical Trials (identifier: IRCT20171230038144N1; https://www.irct.ir/trial/28715, ethical code: IR.IUMS. FMD.REC 1396.9311171014).

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远程缺血预处理在预防有创冠状动脉造影后造影剂肾病中的作用随机对照试验

引言：远程缺血预处理（RIPC）是预防造影剂肾病（CIN）的有效方法；然而，其疗效的结果仍然不确定。目的：我们旨在评估RIPC在冠状动脉造影（CA）后血管成形术患者中预防CIN的有益效果。患者和方法：将100名中高CIN风险的选择性CA和冠状动脉血管成形术候选患者随机分为两组，包括计划RIPC的组和对照组。对两组CIN的总体患病率进行了评估和比较。结果：两组患者在人口统计学、心血管风险状况和实验室参数方面相匹配。RIPC组CIN的发生率为14.0%，对照组为26.0%，两组之间无统计学差异（P=0.105）。需要透析的患者也分别为0.0%和2.0%，无差异（P=0.500）。结论：RIPC可能无法预防侵袭性CA患者的CIN。试验注册：该研究在伊朗临床试验注册中心获得批准（标识符：IRCT2017123003814N1；https://www.irct.ir/trial/28715，道德规范：IR.IUMS.FMD.REC 1396.9311171014）。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.