Liver failure progresses rapidly and has a high mortality rate. Since its development in 1986, Li's artificial liver has gradually formed a unique and highly effective treatment system, which is widely used in the treatment of liver failure. The Li's artificial liver system (Li ALS) integrates various purification methods such as plasma exchange, plasma perfusion, and hemofiltration, providing a homogeneous treatment plan for liver failure. Choosing the timing of artificial liver treatment, screening biomarkers related to artificial liver, and combining them with new treatment methods for liver failure are potential development directions for Li's artificial liver.