Effect of levetiracetam and valproate on late-onset post-traumatic seizures.

IF 1.2 Q4 CLINICAL NEUROLOGY

Acta Epileptologica Pub Date : 2023-04-23 DOI:10.1186/s42494-023-00121-8

Yanli Wang, Yiqi Wang, Huifang Wang, Xiaoping Du, Jie Miao, James X Tao, Meizhen Sun

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Abstract

Background: To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury (TBI).

Methods: A total of 95 patients with TBI were recruited from 2017 to 2020. They were randomized into three groups: levetiracetam (LEV) group (n = 30) receiving LEV treatment (500 mg, bid, po); valproate group (n = 32) receiving sodium valproate (500 mg/d, once daily, po); and control group (n = 33) receiving no anti-seizure medication. LEV and valproate were given to corresponding groups within seven days after TBI, and the administration lasted for one month. The incidence of epilepsy and adverse events were evaluated at 7 days and 12 months post-TBI.

Results: The cumulative incidences of late post-traumatic seizures at the 12-month follow-up in the LEV, valproate, and control groups were 3.33%, 12.50% and 15.63%, respectively. The cumulative incidence of late post-traumatic seizures in the LEV group was significantly lower than those in the valproate and control groups (P < 0.05). The cumulative incidence of late post-traumatic seizure in the valproate group was not significantly different from that in the control group (P > 0.05).

Conclusions: LEV can reduce the cumulative incidence of late post-traumatic seizures, whereas valproate can not.

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左乙拉西坦和丙戊酸钠对迟发性创伤后癫痫发作的影响

背景：比较左乙拉西坦与丙戊酸钠对颅脑损伤（TBI）患者迟发性创伤后癫痫发作的预防作用。方法：2017 - 2020年共招募95例TBI患者。随机分为3组：左乙拉西坦（LEV）组（n = 30）给予LEV治疗（500 mg, bid, po）；丙戊酸组（n = 32）给予丙戊酸钠（500 mg/d，每日1次，po）；对照组（33例）不给予抗癫痫药物治疗。相应组在脑外伤后7天内给予LEV和丙戊酸钠，连续用药1个月。分别在tbi后7天和12个月评估癫痫和不良事件的发生率。结果：随访12个月，LEV组、丙戊酸组和对照组的创伤后晚期癫痫累计发生率分别为3.33%、12.50%和15.63%。LEV组创伤后晚期癫痫发作累积发生率显著低于丙戊酸组和对照组（P < 0.05）。结论：LEV可降低创伤后晚期癫痫发作的累积发生率，而丙戊酸不能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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