Omega 3 Supplementation Improves Inflammation and Antioxidant Defense in Women with Polycystic Ovary Syndrome

IF 0.8 Q4 NUTRITION & DIETETICS

Current Nutrition & Food Science Pub Date : 2021-11-04 DOI:10.2174/1573401317666211104121725

Latifa Imen Benharrat, Azzeddine Senouci, Wassila Benhabib, K. Mekki

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Abstract

Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is accompanied by metabolic syndrome (MS), a risk factor for cardiovascular disorders. To evaluate the effect of Omega 3 on the improvement of some metabolic parameters. Sixty women (29±6 years) with PCOS and MS were randomized into two groups: 30 received supplementation with omega-3 (Doppelherz, Activ, Germany), 3g/day (1g per capsule and 3 capsules/day), (180mg Eicosapentaenoic Acid (EPA)/ 120mg Docosahexaenoic Acid DHA per day), and 30 were used as controls. Blood samples were drawn at baseline (T0), 3 weeks (T1) and 6 weeks (T2) after start of treatment. We analysed glycemia, lipid profile, markers of inflammation and oxidative stress. In omega-3 group compared to control, a reduction (p<0.05) in glucose levels was noted at T1 and T2. C-reactive protein (CRP) concentrations were decreased (-25%) at T2. Oxidative stress remain unchanged, but the activity of superoxide dismutase increased as well as the concentrations of Catalase and thiols at T1 and T2 (p<0.001). Omega 3 supplementation improves hyperglycemia, inflammation, and antioxidant defense in PCOS women with MS, and may lead to decreased cardiovascular complications

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补充欧米茄3改善多囊卵巢综合征妇女的炎症和抗氧化防御

多囊卵巢综合征（PCOS）是最常见的女性内分泌疾病，并伴有代谢综合征（MS），这是心血管疾病的危险因素。评价欧米茄3对某些代谢参数的改善作用。60名患有多囊卵巢综合征和多发性硬化症的女性（29±6岁）被随机分为两组：30人接受ω-3（Doppelherz，Activ，德国）、3g/天（1gper胶囊和3粒胶囊/天）、180mg二十碳五烯酸（EPA）/120mg二十二碳六烯酸DHA/天）的补充，30人作为对照。在治疗开始后的基线（T0）、3周（T1）和6周（T2）抽取血样。我们分析了血糖、降脂、炎症标志物和氧化应激。与对照组相比，ω-3组在T1和T2时血糖水平下降（p<0.05）。C反应蛋白（CRP）浓度在T2时降低（-25%）。氧化应激保持不变，但在T1和T2时超氧化物歧化酶活性增加，过氧化氢酶和硫醇浓度增加（p＜0.001）。补充欧米茄3可改善患有多发性硬化症的多囊卵巢综合征妇女的高血糖、炎症和抗氧化防御，并可减少心血管并发症

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来源期刊

Current Nutrition & Food Science NUTRITION & DIETETICS-

CiteScore

2.00

自引率

0.00%

发文量

144

期刊介绍： Current Nutrition & Food Science publishes frontier reviews on all the latest advances on basic and clinical nutrition and food sciences. The journal aims to publish the highest quality review articles dedicated to research in the field. The journal is essential reading for all nutrition and food scientists.