Effects of Jinkui Shenqi and Wuzi Yanzong pill on sperm motility and sperm DNA fragmentation rate in asthenospermia

IF 0.6 4区农林科学 Q3 AGRICULTURE, MULTIDISCIPLINARY

Bioscience Journal Pub Date : 2022-12-16 DOI:10.14393/bj-v38n0a2022-54959

Liangliang Xu, Chunhong Xiao, H-Y Cao, Jianfen Yuan, Z. Wu

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Abstract

This study was designed to compare the effects of Jinkui Shenqi and Wuzi Yanzong pill on sperm motility and sperm DNA fragmentation rate in patients with asthenospermia. 130 cases were randomly divided into an observation and control group (n=65). The control group was treated with the Wuzi Yanzong pill while the observation group with the Jinkui Shenqi pill. The sperm motility parameters rate (PR), semen concentration, sperm motility, DFI and α-glucosidase, fructose, seminal plasma zinc (Zn), acid phosphatase (ACP) in seminal plasma biochemistry and other indexes of were observed. The biochemical indexes of seminal plasma of α-glucosidase, fructose, Zn, ACP in two groups were significantly (p<0.05) improved after treatment. Compared with the control group, the indexes of the observation group improved more obviously after treatment. Pearson correlation analysis of DFI and PR indexes in 130 patients before treatment showed that sperm DFI and PR percentage were negatively correlated in asthenospermia patients (r =-0.572, P<0.05). There was no significant difference in DFI, semen concentration, PR, and sperm motility between the two groups before treatment. The DFI, semen concentration, PR and sperm viability of the two groups showed a tendency to improve after treatment, and the effect of the observation group was less significant than that of the control group (p<0.05). Two groups of patients have completed treatment successfully, no adverse events occurred during treatment. Jinkui Shenqi pill can effectively treat asthenospermia, which can effectively improve the effect of sperm motility in patients. It has less adverse reactions, safe and reliable, and is worthy of promotion.

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金葵参芪和五子炎宗丸对弱精子症患者精子活力和DNA断裂率的影响

本研究旨在比较金葵参芪与五子炎宗丸对弱精子症患者精子活力及精子DNA断裂率的影响。130例随机分为观察组和对照组(n=65)。对照组给予五子炎宗丸治疗，观察组给予金葵参芪丸治疗。观察精子活力参数率(PR)、精液浓度、精子活力、DFI及精浆生化中α-葡萄糖苷酶、果糖、精浆锌(Zn)、酸性磷酸酶(ACP)等指标。两组精浆α-葡萄糖苷酶、果糖、锌、ACP等生化指标治疗后均显著(p<0.05)提高。与对照组比较，观察组治疗后各项指标改善更为明显。130例患者治疗前DFI与PR指标Pearson相关分析显示，弱精子症患者精子DFI与PR百分比呈负相关(r =-0.572, P<0.05)。两组治疗前DFI、精液浓度、PR、精子活力均无显著差异。两组患者治疗后DFI、精液浓度、PR、精子活力均有改善趋势，但观察组效果低于对照组(p<0.05)。两组患者均顺利完成治疗，治疗期间无不良事件发生。金葵参芪丸能有效治疗弱精子症，能有效改善患者精子活力的效果。不良反应少，安全可靠，值得推广。

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来源期刊

Bioscience Journal Agricultural and Biological Sciences-General Agricultural and Biological Sciences

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

48 weeks

期刊介绍： The Bioscience Journal is an interdisciplinary electronic journal that publishes scientific articles in the areas of Agricultural Sciences, Biological Sciences and Health Sciences. Its mission is to disseminate new knowledge while contributing to the development of science in the country and in the world. The journal is published in a continuous flow, in English. The opinions and concepts expressed in the published articles are the sole responsibility of their authors.