Epigenetic dysregulation in pituitary tumors

IF 1.2
O. Shariq, K. Lines
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引用次数: 3

Abstract

Pituitary tumors are common intracranial neoplasms associated with significant morbidity due to hormonal dysregulation and neurologic symptoms. Somatic mutations are uncommon in sporadic pituitary adenomas, and only few monogenic conditions are associated with pituitary tumors. However, increasing evidence suggests that aberrant epigenetic modifications are found in pituitary tumors. In this review, we describe these mechanisms, including DNA methylation, histone modification and microRNA expression, and the evidence supporting their dysregulation in pituitary tumors, as well as their regulation of pro-tumorigenic genes. In addition, we provide an overview of findings from preclinical studies investigating the use of histone deacetylase inhibitors to treat pituitary adenomas and the need for further studies involving epigenetic drugs and functional characterization of epigenetic dysregulation.
垂体肿瘤的表观遗传失调
垂体瘤是一种常见的颅内肿瘤,由于激素失调和神经系统症状,发病率很高。体细胞突变在散发性垂体腺瘤中并不常见,只有少数单基因情况与垂体瘤有关。然而,越来越多的证据表明,在垂体瘤中发现了异常的表观遗传学修饰。在这篇综述中,我们描述了这些机制,包括DNA甲基化、组蛋白修饰和微小RNA表达,以及支持它们在垂体瘤中失调的证据,以及它们对促肿瘤基因的调节。此外,我们还概述了组蛋白脱乙酰酶抑制剂用于治疗垂体腺瘤的临床前研究结果,以及进一步研究表观遗传学药物和表观遗传学失调功能特征的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
0
审稿时长
13 weeks
期刊介绍: International Journal of Endocrine Oncology is a quarterly, peer-reviewed journal that helps the clinician to keep up to date with best practice in this fast-moving field. The journal highlights significant advances in basic and translational research, and places them in context for future therapy. The journal presents the latest research findings in diagnosis and management of endocrine cancer, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. The journal welcomes the unsolicited submission of article proposals and original research manuscripts.
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