Efficacy of various proton-pump inhibitors and calcium hydroxide as intracanal medicaments against Enterococcus Faecalis: An in vitro study

Q3 Dentistry

Endodontology Pub Date : 2022-10-01 DOI:10.4103/endo.endo_102_22

Tejas Koparkar, S. Kalyan, Lalitagauri P. Mandke, Mansi Vandekar

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引用次数: 1

Abstract

Aim: The purpose of this study was to compare the efficacy of four proton-pump inhibitors (PPIs) (pantoprazole, omeprazole, lansoprazole, and rabeprazole) when combined with calcium hydroxide and used as intracanal medicaments against Enterococcus faecalis. Methods: A total of 550 microliters of E. faecalis strain was inoculated into two mixtures 6.25 μg/ml and 25 μg/ml containing calcium hydroxide (concentration 16 mg/ml) and PPIs (concentration 1 mg/ml). The efficacy was evaluated by comparing the optical density of the mixtures at 630 nm with two time parameters of 18 h and 24 h. Results: At 18 h, O6 (calcium hydroxide and omeprazole 6.25 μg/ml) showed the maximum percentage inhibition of E. faecalis strain and R25 (calcium hydroxide and rabeprazole 25 μg/ml) showed the least inhibition. At 24-h time interval, O6 showed the maximum inhibition, while R6 (calcium hydroxide and rabeprazole 6.25 μg/ml) showed the least inhibition of E. faecalis strain. Conclusion: The use of PPIs with calcium hydroxide did show promising results and the combination could be used successfully as an intracanal medicament.

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各种质子泵抑制剂和氢氧化钙作为肛管内药物对粪肠球菌的疗效:体外研究

目的：本研究的目的是比较四种质子泵抑制剂（PPIs）（泮托拉唑、奥美拉唑、兰索拉唑和雷贝拉唑）与氢氧化钙联合用作肛门内药物治疗粪肠球菌的疗效。方法：将550微升粪肠球菌菌株接种到含有氢氧化钙（浓度16 mg/ml）和PPIs（浓度1 mg/ml）的6.25μg/ml和25μg/ml两种混合物中。通过比较混合物在630nm处的光密度与18小时和24小时的两个时间参数来评估疗效。结果：在18小时，O6（氢氧化钙和奥美拉唑6.25μg/ml）对粪肠球菌菌株的抑制率最高，R25（氢氧化钙与雷贝拉唑25μg/ml）的抑制率最低。在24小时的时间间隔内，O6表现出最大的抑制作用，而R6（氢氧化钙和雷贝拉唑6.25μg/ml）对粪肠球菌菌株的抑制作用最小。结论：PPIs与氢氧化钙联合应用确实显示出良好的效果，该组合可以成功地用作肛门内药物。

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