COVID-19-associated Guillain‒Barre syndrome: Is it parainfectious or postinfectious?

Q4 Medicine
A. Singh, Rothangpui, M. Singh, R. Thangjam, Ch Shivaranjan
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引用次数: 0

Abstract

COVID -19 since its inception from the month of December 2019 has been associated with myriads of systemic complication apart from the respiratory failure, with Guillain-Barre syndrome (GBS) being one of the prominent neurological complication. More than 220 patients with GBS have been reported thus far. We wish to share 3 cases of GBS associated with COVID 19 admitted in our institute. GBS is one of the most common causes of acute, acquired weakness and is often provoked by a preceding infection, which triggers an immune response, cross-reacts with shared epitopes on peripheral nerve (molecular mimicry). Interestingly one of the cases developed limb weakness concurrently with the respiratory symptoms, probably during the viremic phase; the other 2 cases few weeks after recovering from COVID 19. So, is there a specific association with covid 19 and GBS? If associated, is it Para infectious or Post infectious? Further studies are needed to unravel its association with COVID 19.
covid -19相关格林-巴利综合征:是副感染还是感染后?
COVID-19自2019年12月成立以来,除了呼吸衰竭外,还与多种系统性并发症有关,格林-巴利综合征(GBS)是一种突出的神经系统并发症。迄今为止,已有220多名GBS患者的报告。我们希望分享我们研究所收治的3例与COVID 19相关的GBS病例。GBS是急性获得性虚弱最常见的原因之一,通常由先前的感染引起,从而引发免疫反应,与外周神经上的共享表位发生交叉反应(分子模拟)。有趣的是,其中一例在出现呼吸道症状的同时出现四肢无力,可能是在病毒血症阶段;其他2例在新冠肺炎19康复几周后。那么,新冠肺炎19和GBS之间是否存在特定关联?如果相关,是准传染性还是后传染性?需要进一步的研究来解开它与新冠肺炎的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JMS - Journal of Medical Society
JMS - Journal of Medical Society Medicine-Medicine (all)
CiteScore
0.20
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