A histopathological study on the effects of atorvastatin against gentamicin-induced renal injury

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2022-01-10 DOI:10.34172/jrip.2022.32013

Elham Emami, A. Hasanpour Dehkordi, A. Maghsoudi, H. Nasri, Alireza Vahedi

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引用次数: 0

Abstract

Introduction: Gentamicin is an aminoglycoside antibiotic that is widely administered to treat infections caused by gram-negative bacteria. Gentamicin may cause renal injury in patients after seven days of administration. Atorvastatin is a cholesterol-lowering statin that acts through the mevalonate pathway. Objectives: In this study, we investigated the histopathological effects of atorvastatin against gentamicin-induced renal injury. Materials and Methods: Twenty male Wistar rats were randomly assigned into five groups and treated as the following; group 1 (normal group, no drug), group 2 [gentamicin group, daily 80 mg/kg, intra-peritoneal (i.p.) for 7 days], groups 3 to 5 (gentamicin 80 mg/kg + atorvastatin at doses of 5, 25 and 75 mg/kg, respectively). Kidney sections were examined for histopathological parameters including vacuolization of the kidney tubular cells, degeneration, necrosis, flattening of the tubular cells and debris in the tubular lumen. Results: Compared to the normal group, gentamicin significantly exacerbated the histopathological parameters. Treatment with atorvastatin significantly decreased vacuolization, degeneration, necrosis and debris in the nephrotoxic rats. Conclusion: The findings of this research indicated that atorvastatin therapy can ameliorate histopathological renal injury following gentamicin injection.

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阿托伐他汀抗庆大霉素肾损伤作用的组织病理学研究

简介：庆大霉素是一种氨基糖苷类抗生素，广泛用于治疗革兰氏阴性菌引起的感染。庆大霉素给药7天后可能导致患者肾损伤。阿托伐他汀是一种通过甲羟戊酸途径发挥作用的降胆固醇他汀。目的：在本研究中，我们研究阿托伐他汀对庆大霉素诱导的肾损伤的组织病理学作用。材料与方法：雄性Wistar大鼠20只，随机分为5组，按以下方法处理；第1组（正常组，无药物），第2组[庆大霉素组，每日80mg/kg，腹膜内（i.p.）7天]，第3至第5组（庆大霉素80mg/kg+阿托伐他汀，剂量分别为5、25和75mg/kg）。检查肾脏切片的组织病理学参数，包括肾小管细胞的空泡化、变性、坏死、小管细胞的扁平化和管腔中的碎片。结果：与正常组相比，庆大霉素显著加重了组织病理学参数。阿托伐他汀治疗显著减少肾毒性大鼠的空泡化、变性、坏死和碎片。结论：本研究结果表明阿托伐他汀治疗可以改善庆大霉素注射后的组织病理学肾损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.