The Prevalence of Low Birth Weight in Children with Nephrotic Syndrome

Q3 Medicine

Journal of Comprehensive Pediatrics Pub Date : 2023-07-23 DOI:10.5812/compreped-133658

S. Sadeghi-bojd, E. Zarifi, Motahare Alisofi, Saeideh Sarhadi

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Abstract

Background: Nephrotic syndrome (NS) is a common disease in children with many consequences for their health, particularly when the disease is severe, accompanied by frequent recurrences, and must be treated with high-dose, long-term corticosteroids. Objectives: We aimed to determine the effect of birth weight on complete response to corticosteroids in children with NS. Methods: Two hundred and ninety-two children with NS aged 1 - 18 years were included in the present cross-sectional study. The children followed up from 2010 to 2021 at Ali-Ibn-e-Abitaleb Hospital, Zahedan, Iran. Data were obtained by reviewing medical records for results and completing a parental self-reported questionnaire for birth-related information. For the analysis, SPSS 23 was applied with P < 0.05 as a significance level. Results: In the steroid-resistant (28.9%) group, low birth weight (LBW) was significantly higher than in the steroid-sensitive (10.5%) group (P = 0.001). A two-way logistic regression report showed that birth weight (P = 0.04, OR = 0.58, 95% CI: 0.34 - 0.99) and number of recurrences (P = 0.001, OR = 4.60, 95% CI: 2.91 - 7.27) were both significantly associated with the development of steroid resistance. Conclusions: In patients with NS, there was a significant association between LBW, higher relapse rates, steroid resistance, and thus poorer patient outcomes.

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肾病综合征患儿低出生体重的患病率

背景：肾病综合征（NS）是儿童的一种常见疾病，对他们的健康有许多影响，尤其是当疾病严重并伴有频繁复发时，必须使用高剂量、长期的皮质类固醇治疗。目的：我们旨在确定出生体重对NS儿童皮质类固醇完全反应的影响。方法：将2192名1-18岁的NS儿童纳入本横断面研究。这些孩子于2010年至2021年在伊朗扎黑丹Ali-Ibn-e-Abitaleb医院接受了随访。数据是通过审查医疗记录的结果和填写父母自我报告的出生相关信息问卷获得的。应用SPSS 23软件进行分析，P＜0.05为显著性水平。结果：激素耐药组（28.9%），低出生体重（LBW）明显高于类固醇敏感组（10.5%）（P=0.001）。双向logistic回归报告显示，出生体重（P=0.04，OR=0.58，95%CI:0.34-0.99）和复发次数（P=0.001，OR=4.60，95%CI:2.91-7.27）均与类固醇耐药性的发展显著相关。结论：在NS患者中，LBW、更高的复发率、类固醇耐药性和较差的患者预后之间存在显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Comprehensive Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Journal of Comprehensive Pediatrics is the official publication of Iranian Society of Pediatrics (ISP) and a peer-reviewed medical journal which is published quarterly. It is informative for all practicing pediatrics including general medical profession.