Updates in Basic Research on Molecular Genetic Background of Pulmonary Hypertension

Abstract

With dramatic advances in the eld of molecular genetics, the investigation of the genetic background in pulmonary hypertension has also remarkably improved. In 2018, the 6th World Symposium on Pulmonary Hypertension (6th WSPH) identi ed 17 genes as causative factors for pulmonary arterial hypertension (PAH). In this review, the author discusses the candidate causative genes of PAH that have been identi ed consecutively a er the 6th WSPH. Furthermore, interesting reports on new modi er and susceptibility genes for PAH and the methods of interpreting these genes are discussed. is review also presents other noteworthy basic studies.