Modulation of Glucose Homeostasis in Rats Treated with Bacterial Lipopolysaccharide: Role of L-Arginine Counter-Strategy

Abstract

Lipopolysaccharide (LPS), an endotoxin derived from the outer membrane of Gram-negative bacteria, mediates a local or systemic inflammatory response. Its action is carried out through stimulation of Toll-like receptor 4 (TLR4) activity and subsequently, production of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)