Low-intensity pulsed ultrasound improvedthe regeneration ofinjuried peripheral nerve

Abstract

Objective Observe the effect of low-intensity pulsed ultrasound on regeneration after peripheral nerve injury. Methods Eighty rats were randomly divided into implanted and injured rat right sciatic nerve preparation model. The experimental group was treated with low-intensity pulsed ultrasound to treat the experimental group without treatment. The nerve injury of the replacement rats was treated after treatment. The post-regeneration situation is evaluated. Results Rats in the experimental group were treated with SFI and SNCV for 4 week [(29.1±5.1), (11.0±2.7) mm], 6 week [(27.5±4.5), (15.8±2.9) mm], and 8 week [(23.2±4.5), (21.3±2.7) mm]. The time was significantly different from the rats, the difference was statistically significant (t=2.630, 3.060, 3.140, 2.280, 2.650, 5.120, P<0.05); 2 week [(188.2±33.4) no/mm2], the nerve fiber density of the experimental group was slightly lower than that of the rats, implanted for 4 week [(2 385.4±394.2) no/mm2], 6 week [(2 439.4±334.2) no/mm2] and 8 week [(3 259.7±416.7) no/mm2], the nerve fiber density of the experimental group was significantly higher than the above rats, the difference was statistically significant (t=2.240, 2.430, 2.740, 3.280, P<0.05); the rats in the experimental group had a mean nerve regeneration rate of 4 week [(1.42±0.44) mm/d], 6 week [(1.48±0.44) mm/d] and 8 week [(1.29±0.28) mm/d]. Focusing on rats, the difference was statistically significant (t=2.500, 2.840, 3.070, P<0.05); the nerve fiber regeneration and Schwann cell proliferation in the experimental group were significantly replaced by rats. Conclusion Low-intensity pulsed ultrasound can effectively promote regeneration after peripheral nerve injury, and the nerve function is effectively restored, and the effect is remarkable. Key words: Low intensity pulsed ultrasound; Peripheral nerve; Damage; Regeneration; Experimental study