Squamous Cell Carcinoma Arising from Linear Porokeratosis - a case report and review of the literature

Serbian Journal of Dermatology and Venereology Pub Date : 2017-12-20 DOI:10.1515/sjdv-2017-0019

S. Radoš, M. Milovanović, Milica Rajović, K. Kostić, I. Tufegdžić, L. Kandolf Sekulovič

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Abstract

Abstract Porokeratosis belongs to a group of disorders of keratinization that are characterized by the histopathological feature of the cornoid lamella, a column of tightly fitted parakeratotic cells. The etiology of porokeratosis is still unclear. Different variants of porokeratosis (PK) have been subsequently recognized, each with its own specific properties in terms of morphology, distribution and clinical course. Linear porokeratosis is one of the variants of porokeratosis, a rare disorder of keratinization that may develop into several epidermal malignancies, squamous cell carcinoma being the most frequent among all of them. Thus, a clinical surveillance for malignancy is an imperative. We present a case of a 54-year-old man with non-healing ulcer of the lower leg caused by squamous cell carcinoma arising on long-standing linear porokeratosis. The treatment included wide excision of tumor with the reconstruction of the area. Acitretin was prescribed for linear porokeratosis treatment. The follow-up of our patient so far has shown that he does not have new malignant lesions after surgical excision.

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鳞状细胞癌由线状角化症引起- 1例报告及文献复习

摘要：角膜溃疡病属于一组角化障碍，其特征是角质层的组织病理学特征，角质层是一列紧密贴合的角化不良细胞。多孔性角化病的病因尚不清楚。随后，人们发现了不同的多孔角化症（PK）变体，每种变体在形态、分布和临床过程方面都有其独特的特性。线状孔角化症是孔角化症的变体之一，这是一种罕见的角化障碍，可能发展为几种表皮恶性肿瘤，鳞状细胞癌是其中最常见的。因此，恶性肿瘤的临床监测势在必行。我们报告了一例54岁的男性，其小腿溃疡由鳞状细胞癌引起，该鳞状细胞癌是由长期的线状多孔角化引起的。治疗包括广泛切除肿瘤并重建该区域。阿曲汀用于治疗线状多孔性角化病。到目前为止，我们对患者的随访表明，手术切除后，他没有新的恶性病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Serbian Journal of Dermatology and Venereology

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期刊介绍： Serbian Journal of Dermatology and Venereology is a journal of the Serbian Association of Dermatologists and Venereologists. The journal is published in English, quarterly and intended to provide rapid publication of papers in the field of dermatology and venereology. Manuscripts are welcome from all countries in the following categories: editorials, original studies, review articles, professional articles, case reports, and history of medicine.