Incidence of Dengue Infection among Febrile Patients in Port Sudan

AreegSalih Abdel Aziz Ahmed, Tahani Bashir Mohammeddeen Ahmed
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Abstract

Objective: Aiming to detect dengue virus antibodies in clinically suspicious patients’ serum, contributing to clinical and laboratory advancements in dengue infection management, exploring the association between a clinico-laboratory makeup and Dengue fever, and enhancing the capacity to anticipate, diagnose, and respond to dengue infection. Methods: At Port Sudan 2015, a descriptive cross-sectional hospital-based study was implemented. Six tertiary care hospitals in Port Sudan were included in the report. Patients who attended assigned hospitals with a suspected dengue infection were investigated. Individuals who are at least 9 months old, residency in study area for at least 7 days, pyrexia with unspecified cause for 2-7 days, thrombocytopenia in malaria negative blood film, as well as ages of 9 months and older considerably involved. Gender, age, residency, and clinical symptoms were used as independent variables while dengue patients posing as the dependent variable. Sample size approximation was created based on previous African community studies. To target respondents, a randomized cluster model was used. Information was gathered through direct interview, as well as questionnaire after signed a consent form. 5ml of venous blood withdraw by a professional nurse from each respondent, then examined for hematological indicators of dengue fever using Sysmex XP-300 Automated Hematology Analyzerand dengue specific IgM antibodies using Panbio® Dengue IgM Capture ELISA. Entering data and analysis of the volunteers’ characteristics, the Statistical Package for Social Sciences program (SPSS Inc., Chicago, IL, USA) version 20 was used. Incredibly simple descriptive statistics were used to analyze the laboratory results of the Dengue indicators as well as risk factors. Results: The study involved 83 cases out of 110 that were tested by ELISA at different hospitals in Port Sudan and determined to be diagnosed with the dengue virus.The incidence rate among febrile patients was 75% (68 cases), with DF documented in 80 cases (96%) and DHF in three scenarios (4%). higher prevalence within the (21-30) age category 50/110. (45%).High occurrence rate during July (63 cases) (57%). Fever was the most noticeable clinical feature 79/83(95%, more evident hematological indicators included thrombocytopenia and leucopenia (88%) 97 out of 110 (71%) 78/110 in each event. Most of study subjects were unaware regarding risk factors with exception of transmission mode. Conclusions: Study reported high incidence among suspected febrile participants. Most of patients presented as DF, with greater occurrence among reproductive age group and during July.Thrombocytopenia and leucopenia were more prominent clinical manifestations.With the exception of the mode of transmission, the majority of study respondents were unaware of the risk factors.
苏丹港发热病人中登革热感染的发病率
目的:旨在检测临床可疑患者血清中的登革热病毒抗体,为登革热感染管理的临床和实验室进展做出贡献,探索临床实验室构成与登革热之间的关系,提高预测、诊断和应对登革热感染的能力。方法:2015年在苏丹港进行了一项描述性的横断面医院研究。报告中包括苏丹港的六家三级护理医院。对在指定医院就诊的疑似登革热感染患者进行了调查。至少9个月大、在研究区居住至少7天、不明原因发热2-7天、疟疾阴性血片中的血小板减少症,以及9个月及以上的患者。性别、年龄、居住地和临床症状被用作自变量,登革热患者被用作因变量。样本量近似值是根据以前的非洲社区研究得出的。为了针对受访者,使用了随机聚类模型。通过直接访谈和签署同意书后的问卷调查收集信息。由一名专业护士从每位受访者中抽取5ml静脉血,然后使用Sysmex XP-300自动血液学分析仪检查登革热的血液学指标,并使用Panbio®登革热IgM捕获ELISA检查登革热特异性IgM抗体。输入数据并分析志愿者的特征,使用社会科学统计包程序(SPSS股份有限公司,芝加哥,伊利诺伊州,美国)第20版。令人难以置信的简单描述性统计被用于分析登革热指标的实验室结果以及风险因素。结果:这项研究涉及110例病例中的83例,这些病例在苏丹港的不同医院进行了ELISA检测,并被诊断为登革热病毒。发热患者的发病率为75%(68例),DF记录为80例(96%),DHF记录为3种情况(4%)。(21-30)年龄组50/110人群中患病率较高。7月发病率高(63例)(57%)。发热是最明显的临床特征79/83(95%),更明显的血液学指标包括血小板减少症和白细胞减少症(88%),110例中有97例(71%)78/110例。除传播方式外,大多数受试者对风险因素一无所知。结论:研究报告了疑似发热参与者的高发病率。大多数患者表现为DF,生殖年龄组和7月发生率更高。血小板减少和白细胞减少是更突出的临床表现。除了传播方式外,大多数研究对象都不知道风险因素。
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