Probiotic Lactobacillus plantarum IS-10506, Expression of Glial Fibrillary Acidic Protein and Platelet Endothelial Cell Adhesion Molecule-1 by Astrocytes and Endothelial Integrity: The Importance of Intestinal Microbiota as Blood Brain–Barrier Stabilizer

Q4 Medicine

International Journal of Probiotics and Prebiotics Pub Date : 2022-02-11 DOI:10.37290/ijpp2641-7197.17:21-26

R. Ranuh, A. F. Athiyyah, A. Darma, W. Riawan, P. Gunawan, I. Surono, S. Sudarmo

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引用次数: 1

Abstract

Gut microbiota is a complex community that helps maintain the dynamic metabolic ecological balance of the brain through the gut–brain axis and keeps the blood–brain barrier structure intact. However, the knowledge of how the gut microbiota responds to exogenous influences on the blood–brain barrier structure remains limited. This study hypothesizes that probiotic Lactobacillus plantarum IS 10506 supplementations could ameliorate the disruption of the blood–brain barrier structure. To this end, we examined effect of the probiotic L. plantarum IS 10506 on the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1 in the control and E. coli serotype O55:B5 lipopolysaccharide treated blood–brain barrier disruption model of Wistar rats. The rats receiving L. plantarum IS 10506 alone or along with E. coli serotype O55:B5 lipopolysaccharide exhibited upregulation of the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1. In conclusion, the probiotic L. plantarum IS-10506 stimulates the restoration of blood–brain barrier disruption.

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胶质纤维酸性蛋白和血小板内皮细胞粘附分子-1在星形胶质细胞和内皮细胞完整性中的表达:肠道微生物群作为血脑屏障稳定剂的重要性

肠道微生物群是一个复杂的群落，有助于通过肠脑轴维持大脑的动态代谢生态平衡，并保持血脑屏障结构的完整性。然而，关于肠道微生物群如何对血脑屏障结构的外源性影响做出反应的知识仍然有限。本研究假设益生菌植物乳杆菌IS 10506补充剂可以改善血脑屏障结构的破坏。为此，我们检测了益生菌植物乳杆菌IS 10506对对照和大肠杆菌O55:B5型脂多糖处理的Wistar大鼠血脑屏障破坏模型中神经胶质原纤维酸性蛋白和血小板内皮细胞粘附分子-1表达的影响。单独或与大肠杆菌血清型O55:B5脂多糖一起接受植物乳杆菌IS 10506的大鼠表现出神经胶质原纤维酸性蛋白和血小板内皮细胞粘附分子-1的表达上调。总之，益生菌植物乳杆菌IS-10506刺激血脑屏障破坏的恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Probiotics and Prebiotics Nursing-Nutrition and Dietetics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： The International journal of Probiotics & Prebiotics publishes on online only in an open access format. This is a broad based international, interdisciplinary peer reviewed scientific journal for critical evaluation of research on prebiotics, probiotics and synbiotics. The major goal of this journal is to provide unbiased scientific data to students, researchers, healthcare providers, and the decision makers in the nutraceutical industry to help make informed choices about prebiotics, probiotics and synbiotics. To this end, the journal will publish original research articles and two types of review articles. First, we will publish a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, we will publish a critical evaluation of current human experimental data to help deliver products with medically proven use.