Global Hotspots and Frontier Landscapes of DNA Methylation in Reproductive Medicine (1993-2020): A Scientometric Analysis

4区医学

Tobacco Regulatory Science Pub Date : 2021-11-03 DOI:10.18001/trs.7.6.124

Yuan Li, F. Lian, Ying Guo, Haicui Wu, S. Xiang

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引用次数: 0

Abstract

BACKGROUND: DNA methylation is a major epigenetic modification of genomes in mammals, involving the regulation of many cellular processes. Increasing study focus on the correlation between DNA methylation and reproductive medicine. Thus, it is meaningful to systematically review the latest knowledge domain and provide a hallmark of DNA methylation in reproductive medicine. This study aimed to quantitatively analyze the intellectual structure, hot topics and emerging trends of DNA methylation-related studies in reproductive medicine using visualization software. METHODS: In the present study, we perform a qualitatively and quantitatively evaluation on publications about DNA methylation in reproductive medicine, using a visual exploration tool CiteSpace, to identify emerging trends and transient patterns in scientific literature. RESCULTS: A total of 660 records relating DNA methylation in reproductive medicine were retrieved the Web of Science core collection from 1993 to 2020. The number of the annual publications gradually increased. CiteSpace 5.3 was used to comprehensively analyze the publication information. Fertility and Sterility published the highest number of studies on DNA methylation. Nature and New England Journal of Medicine ranked the first in the frequency and centrality of cited journal. Among countries, the United States was the publication leader, and the top institute was Chinese Academy of Sciences with the most productions. Haaf T was the most representative author. Gene expression, epigenetics, in vitro fertilization, assisted reproductive technology, fertilization, and beckwith Wiedemann syndrome were the hot spots, and endocrine disruptor, genome-wide analysis, and the safety of assisted reproductive technology represented research frontiers. CONCLUSION: Scientometric analysis identifies that DNA methylation is still a hot topic in reproductive medicine, and provides valuable information for researchers to identify new perspectives on potential collaborators and cooperative institutions and shape the future research directions.

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生殖医学中DNA甲基化的全球热点和前沿景观（1993-2020）：科学分析

背景：DNA甲基化是哺乳动物基因组的主要表观遗传学修饰，涉及许多细胞过程的调控。越来越多的研究关注DNA甲基化和生殖医学之间的相关性。因此，系统地回顾最新的知识领域并提供生殖医学中DNA甲基化的标志是有意义的。本研究旨在利用可视化软件定量分析生殖医学中DNA甲基化相关研究的知识结构、热点和新趋势。方法：在本研究中，我们使用视觉探索工具CiteSpace对生殖医学中DNA甲基化的出版物进行了定性和定量评估，以确定科学文献中的新趋势和瞬态模式。结果：从1993年到2020年，共有660份与生殖医学中DNA甲基化有关的记录被检索到科学网的核心收藏中。年度出版物的数量逐渐增加。CiteSpace 5.3用于对出版物信息进行综合分析。《生育与不育》发表的关于DNA甲基化的研究数量最高。《自然》和《新英格兰医学杂志》在被引用期刊的频率和中心性方面排名第一。在各国中，美国是出版物的领导者，中国科学院是产量最高的研究所。哈夫·T是最具代表性的作家。基因表达、表观遗传学、体外受精、辅助生殖技术、受精和beckwith-Wiedmann综合征是研究热点，内分泌干扰物、全基因组分析和辅助生殖技术的安全性是研究前沿。结论：科学分析表明，DNA甲基化仍然是生殖医学的热门话题，并为研究人员确定潜在合作者和合作机构的新视角和确定未来的研究方向提供了有价值的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tobacco Regulatory Science Multiple-

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