Propofol and sleep disorders

国际麻醉学与复苏杂志 Pub Date : 2020-02-15 DOI:10.3760/CMA.J.ISSN.1673-4378.2020.02.018

Pei Wang, Huai-long Chen, Weiwei Qin, Mingshan Wang

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Abstract

Sleep is an important physiological activity to maintain normal physiological functions of human body. With the acceleration of human life rhythm, the number of sleep disorders is increasing gradually at the same time. At present, many studies have shown that general anesthetics can cause loss of consciousness by acting on the sleep-wake circuit, and thus have a certain impact on human sleep in a short period of time. Propofol is one of the general anesthetics. Further observation and discussion of the effects of propofol on patients with sleep disorders will help to understand the effects of propofol on the prognosis and rehabilitation of patients. But studies on propofol and sleep disorders are rare. In this paper, by introducing the mechanism and regulating factors of sleep, the mechanism and influencing factors of sleep disorder, effect of propofol on sleep and its molecular targets leading to loss of consciousness are summarized. Also, the possible effects and underlying mechanisms of propofol on sleep disorders are summarized. Key words: Propofol; Anesthetics, general; Loss of consciousness; Sleep; Sleep disorder

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异丙酚和睡眠障碍

睡眠是维持人体正常生理机能的重要生理活动。随着人类生活节奏的加快，睡眠障碍的数量也在逐渐增加。目前，许多研究表明，全身麻醉剂通过作用于睡眠-觉醒回路而导致意识丧失，从而在短时间内对人的睡眠产生一定的影响。异丙酚是一种全身麻醉剂。进一步观察和探讨异丙酚对睡眠障碍患者的影响，有助于了解异丙酚对患者预后和康复的影响。但是关于异丙酚和睡眠障碍的研究很少。本文通过对睡眠机制和调节因素的介绍，综述了睡眠障碍的机制和影响因素，异丙酚对睡眠的影响及其导致意识丧失的分子靶点。并对异丙酚治疗睡眠障碍的可能作用及机制进行了综述。关键词:异丙酚;麻醉剂,一般;失去知觉;睡眠;睡眠障碍

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国际麻醉学与复苏杂志

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