Role of endothelial cell protein C receptor in hematopoietic stem cells

国际输血及血液学杂志 Pub Date : 2019-05-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.03.015

Xiyan Wang

引用次数: 0

Abstract

Endothelial protein C receptor (EPCR) is one of the components of protein C anticoagulation system, which has important significance in anticoagulation regulation and cell protection. It has been found that EPCR is one of the surface markers of hematopoietic stem cells (HSC) and can be used for sorting and purification of HSC. EPCR can participate in the regulation of HSC and its microenvironment through protease-activated receptor (PAR)1 signaling and other pathways, and it can mediate the retention and hematopoietic function reconstitution of HSC in bone marrow. This article intends to review the application of EPCR in HSC sorting and purification, as well as the research progress of EPCR on the regulation of HSC and its related mechanisms. Key words: Endothelial cells; Hematopoietic stem cells; Protease activated receptor 1; Endothelial protein C receptor; Protein C; Activated protein C

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内皮细胞蛋白C受体在造血干细胞中的作用

内皮蛋白C受体（EPCR）是蛋白C抗凝系统的组成部分之一，在抗凝调节和细胞保护方面具有重要意义。研究发现，EPCR是造血干细胞（HSC）的表面标志物之一，可用于HSC的分选和纯化。EPCR可通过蛋白酶激活受体（标准杆数）1信号传导等途径参与造血干细胞及其微环境的调节，介导骨髓中造血干细胞的滞留和造血功能重建。本文旨在综述EPCR在HSC分选和纯化中的应用，以及EPCR对HSC调控及其相关机制的研究进展。关键词：内皮细胞；造血干细胞；蛋白酶激活受体1；内皮蛋白C受体；蛋白质C；活化蛋白C

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.