A non-equilibrium thermodynamic approach to symmetry breaking in cancer

IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES

Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali Pub Date : 2021-02-01 DOI:10.1478/AAPP.991A1

U. Lucia, Giulia Grisolia, T. Deisboeck

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引用次数: 1

Abstract

This paper develops a non-equilibrium thermodynamics approach to oncogenesis, with a particular focus on ‘symmetry breaking’. The Onsager phenomenological coefficients are introduced to show the biophysical and thermophysical properties of cellular systems with differences between normal and cancerous cells. Seebeck- and Peltier-like effects are introduced to simplify the description of heat exchange and ion fluxes, in an effort to characterize the distinct role of the cellular electric membrane potential. Our result indicate that oncogenesis leads to changes in: (i) the thermophysical properties of the cell cytoplasm, caused by differences in density and heat capacity, (ii) the interactions with the micro-environment, (iii) geometrical characteristics, both in fractal dimensions and in shape symmetry, and (iv) the constitutive properties of membrane fluxes. This presents a unifying biophysics concept for such diverse characteristics, and it may yield new diagnostic and therapeutic opportunities.

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癌症对称性破缺的非平衡热力学方法

本文发展了一种非平衡热力学方法来研究肿瘤的发生，特别关注“对称破缺”。引入Onsager现象学系数来显示正常细胞和癌细胞之间差异的细胞系统的生物物理和热物理特性。塞贝克效应和珀尔蒂埃效应的引入简化了热交换和离子通量的描述，以努力表征细胞电膜电位的独特作用。我们的研究结果表明，肿瘤发生导致以下方面的变化:(i)由密度和热容差异引起的细胞质热物理性质的变化，(ii)与微环境的相互作用，(iii)分形维数和形状对称的几何特征，以及(iv)膜通量的本构性质。这为这些不同的特征提供了一个统一的生物物理学概念，并可能产生新的诊断和治疗机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali MULTIDISCIPLINARY SCIENCES-

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

31 weeks

期刊介绍： This journal is of a multi- and inter-disciplinary nature and covers a broad range of fields including mathematics, computer science, physics, chemistry, biology, earth sciences, and their intersection. History of science is also included within the topics addressed by the journal. The transactions of the Pelorian Academy started out as periodic news sheets containing the notes presented by the members of the Divisions into which the Academy has been and still is organized, according to subject areas. The publication of these notes for the Division (“Classe”) of Mathematical, Physical and Natural Sciences is the responsibility of the Editorial Committee, which is composed of the Director of the division with the role of Chairman, the Vice-Director, the Secretary and two or more other members. Besides original research articles, the journal also accepts texts from conferences and invited talks held in the Academy. These contributions are published in a different section of the journal. In addition to the regular issues, single monographic supplements are occasionally published which assemble reports and communications presented at congresses, symposia, seminars, study meetings and other scientific events organized by the Academy or under its patronage. Since 2004 these transactions have been published online in the form of an open access electronic journal.