Remote ischemic preconditioning combined with atorvastatin improves memory after global cerebral ischemia-reperfusion in male rats

Q3 Pharmacology, Toxicology and Pharmaceutics
A. Hedayatpour, M. Shiasi, Peyman Modarresi, Alieh Bashghareh
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引用次数: 0

Abstract

Introduction: Damage to hippocampus can occur through ischemia. Memory problems are among the most significant disabilities after stroke. Therefore, improving memory is of great interest in helping post-stroke patients. This study demonstrated that intraperitoneally injection of atorvastatin with a short cycle of ischemia-reperfusion in the left femoral artery improved hippocampal CA1 neurons injury and memory problems after global cerebral ischemia. Materials and methods: In this article survey, we used 64 animals. Rats were divided into 8 groups, (n=8). Group 1: control; group 2: sham; group 3: global cerebral ischemia (GCI) only; group 4: remote ischemic preconditioning (RIP) + GCI; group 5: GCI + atorvastatin (ATO); group 6: GCI + vehicle; group 7: RIP + GCI + ATO; group 8: RIP + GCI + vehicle. We created global cerebral ischemia (GCI) with 20 min occlusion of the Common carotid artery. Results and discussion: Remote ischemic preconditioning could improve rats performance in water maze tests along with a decrease in neuronal death. Also, atorvastatin combined with remote ischemic preconditioning was more effective for memory improvement and reduction of neuronal death. Inconsistent with our result, the function of the animals in the ischemia group was impaired. CA1 hippocampal neurons have an important role in memory and learning, and they can be damaged after cerebral ischemia. Therefore, ischemia can create memory problems. Remote ischemic preconditioning and atorvastatin had a neuroprotective effect and could improve rat performance in water maze test. Conclusion: This study showed that remote ischemic preconditioning with atorvastatin could improve CA1 neuronal injury and memory. Graphical abstract:
Remote缺血预处理联合阿托伐他汀可改善雄性大鼠全脑缺血再灌注后的记忆
海马损伤可通过缺血发生。记忆问题是中风后最严重的残疾之一。因此,改善记忆对帮助中风后患者有很大的意义。本研究表明,左股动脉短周期缺血再灌注注射atorvastatin可改善全脑缺血后海马CA1神经元损伤和记忆问题。材料与方法:本研究选用动物64只。将大鼠分为8组(n=8)。第一组:对照组;第二组:假手术;3组:全脑缺血(GCI);4组:远端缺血预处理(RIP) + GCI;第五组:GCI + atorvastatin (ATO);第六组:GCI +车辆;第七组:RIP + GCI + ATO;第八组:RIP + GCI +车辆。我们制造了全脑缺血(GCI),闭塞颈总动脉20分钟。结果与讨论:远端缺血预处理能提高大鼠水迷宫实验的表现,减少神经元死亡。此外,atorvastatin联合远端缺血预处理对改善记忆和减少神经元死亡更有效。与我们的结果不一致的是,缺血组动物的功能受损。CA1海马神经元在记忆和学习中起着重要作用,在脑缺血后会受到损伤。因此,缺血会造成记忆问题。远端缺血预处理和atorvastatin具有神经保护作用,可提高水迷宫实验大鼠的表现。结论:atorvastatin远程缺血预处理可改善CA1神经元损伤及记忆功能。图形化的简介:
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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